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FLASH GENE
Symbol TDRKH contributors: mct - updated : 25-03-2014
HGNC name tudor and KH domain containing
HGNC id 11713
Location 1q21.3      Physical location : 151.744.040 - 151.763.010
Synonym name
  • putative RNA binding protein
  • tudor and KH domain containing protein
  • tudor domain containing 2
  • Synonym symbol(s) TDRD2
    DNA
    TYPE functioning gene
    STRUCTURE 20.27 kb     17 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SCNM1 1q21.3 sodium channel modifier 1 TMOD4 1q12 tropomodulin 4 (muscle) TCFL1 1q21 transcription factor-like 1 PIP5K1A 1q22-q24 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha PSMD4 1q21.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 KIAA1441 1q21.3 KIAA1441 protein PIK4CB 1q21 phosphatidylinositol 4-kinase, catalytic, beta polypeptide RFX5 1q21 regulatory factor X, 5 (influences HLA class II expression) SELENBP1 1q21-q22 selenium binding protein 1 PSMB4 1q21 proteasome (prosome, macropain) subunit, beta type, 4 POGZ 1q21.1 pogo transposable element with ZNF domain CGN 1q21 cingulin TUFT1 1q21-q23 tuftelin 1 SNX27 1q21.3 sorting nexin family member 27 TNRC4 1q21 trinucleotide repeat containing 4 FLJ36032 1q21.3 hypothetical protein FLJ36032 MRPL9 1q21 mitochondrial ribosomal protein L9 OAZ3 1q21.3 ornithine decarboxylase antizyme 3 TDRKH 1q21 tudor and KH domain containing protein LOC339398 1q21.3 similar to DAAT9248 LOC388696 1 LOC388696 RORC 1q21 RAR-related orphan receptor C FLJ37964 1q21.3 hypothetical protein FLJ37964 CTMP 1q21 C-terminal modulator protein LOC391099 1 similar to keratin 8, type II cytoskeletal - human S100A10 1q21 S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) LOC391100 1 similar to KIAA1245 protein S100A11 1q21.2-q22 S100 calcium binding protein A11 (calgizzarin) LOC126637 1q21.3 similar to RIKEN cDNA 5430400H23 THH 1q21 trichohyalin FAM16B 1q21 family with sequence similarity 16, member B FLJ39117 1q21.3 hypothetical protein FLJ39117 LOC388697 1 hypothetical gene supported by AB104446
    regionally located mapped to the epidermal differentiation complex (FDC)
    RNA
    TRANSCRIPTS type messenger
    text multiple, by alterbnative splicing and poliadenylation ; Variants 1, 2, and 3 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2854 62 561 - 2000 10767542
    13 - 2829 62 561 - 2000 10767542
    14 - 2343 62 561 - 2000 10767542
    13 - 2719 57.1 516 - 2000 10767542
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemtestis   
     male systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • TUDOR and KH domains
  • HOMOLOGY
    intraspecies homolog to Iclu (nucleotide-sensitive conductance regulator)
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • playing a role in epithelial function
  • required for spermatogenesis and involved in piRNA biogenesis
  • TDRD1, TDRKH, TDRD9 and TDRD12, function in piRNA biogenesis and retrotransposon silencing
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text differentiation by epidermis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TDRKH partners with PIWIL1 and PIWIL4 via symmetrically dimethylated arginine residues in PIWIL1 and PIWIL4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Tdrkh mutants display meiotic arrest at the zygotene stage, attenuate methylation of Line1 DNA, and upregulate Line1 RNA and protein, without inducing apoptosis