Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | TDRKH | contributors: mct - updated : 25-03-2014 |
HGNC name | tudor and KH domain containing |
HGNC id | 11713 |
|
Location | 1q21.3 Physical location : 151.744.040 - 151.763.010 |
Synonym name | |
| |
| |
Synonym symbol(s) | TDRD2 |
DNA |
TYPE | functioning gene |
STRUCTURE | 20.27 kb 17 Exon(s) |
Genomic sequence alignment details |
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10 Kb 5' upstream gene genomic sequence study |
MAPPING | cloned | Y | linked | N | status | provisional |
regionally located | mapped to the epidermal differentiation complex (FDC) |
RNA |
TRANSCRIPTS | type | messenger |
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text | multiple, by alterbnative splicing and poliadenylation ; Variants 1, 2, and 3 encode the same protein |
EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
|
HOMOLOGY |
intraspecies | homolog to Iclu (nucleotide-sensitive conductance regulator) |
Homologene |
FAMILY |
CATEGORY | RNA associated |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,organelle,mitochondria,outer | |
intracellular,cytoplasm,organelle,membrane |
basic FUNCTION | |
| |
|
CELLULAR PROCESS | cell life, differentiation |
PHYSIOLOGICAL PROCESS |
text | differentiation by epidermis |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
|
| |
ANIMAL & CELL MODELS |
Tdrkh mutants display meiotic arrest at the zygotene stage, attenuate methylation of Line1 DNA, and upregulate Line1 RNA and protein, without inducing apoptosis |