Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TDRD6 contributors: mct - updated : 12-03-2011
HGNC name tudor domain containing 6
HGNC id 21339
Location 6p12.3      Physical location : 46.655.611 - 46.672.054
Synonym name
  • antigen NY-CO-45
  • cancer/testis antigen 41.2
  • tudor repeat 2
  • Synonym symbol(s) CT41.2, DKFZp781I1148, FLJ43850, NY-CO-45, TDR2, bA446F17.4
    DNA
    TYPE functioning gene
    STRUCTURE 16.44 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 8977 236.5 2096 - 1998 9610721
    3 - 8887 233.2 2066 - 1998 9610721
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight different Tudor domains, which potentially could bind multiple distinct arginine methylation marks at the same time
  • HOMOLOGY
    Homologene
    FAMILY tudor domain containing gene family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • essential for spermiogenesis, for chromatoid bodies (characteristic spermatid organelles) structure, and for proper mature and precursor miRNA expression
  • TDRD7 is essential for haploid spermatid development and with TDRD6, are key biogenesis processes of chromatoid bodies
  • TDRD7 and TDRD6 constitute a spermiogenic class of tudor family genes, which function in a sequential and nonredundant manner
  • TDRD7 and TDRD6, play key roles in the early ribonucleoprotein remodeling and later structural maintenance, respectively
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct physical interaction with the chromatoid bodies components PIWIL1 and PIWIL2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS