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FLASH GENE
Symbol TDRD5 contributors: mct - updated : 20-02-2019
HGNC name tudor domain containing 5
HGNC id 20614
Location 1q25.2      Physical location : 179.561.024 - 179.660.398
Synonym symbol(s) FLJ34823, MGC163404
DNA
TYPE functioning gene
STRUCTURE 99.66 kb     18 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3978 - 1035 - 2011 21383078
17 - 3836 - 981 - 2011 21383078
18 - 3711 - 1035 - 2011 21383078
17 - 3677 - 981 - 2011 21383078
14 - 2501 - 536 - 2011 21383078
17 - 3502 - 536 - 2011 21383078
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
Reproductivespermatocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three copies of the LOTUS domain (domain found in germline-specific proteins that are present in the nuage/polar granules of germ cells) in its extreme N-terminus
  • a TUDOR domain, binding symmetric dimethyl arginines present on the germ cell-specific Piwi proteins, which form a particular clade of Argonaute proteins
  • HOMOLOGY
    interspecies homolog to rattus LOC289129
    Homologene
    FAMILY Tudor domain containing protein family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • TDRD5 and TDRD7, play key roles in facilitating the function of PIWIs by acting as scaffolds
  • TDRD5-TDRD7 are required for spermiogenesis
  • TDRD5, TDRD7, RNF17 proteins play distinct roles during male germ cell development
  • is an RNA-binding protein directly associating with piRNA precursors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Tdrd5-deficient round spermatids injected into oocytes contribute to fertile offspring, demonstrating that acquisition of a functional haploid genome may be uncoupled from TDRD5 function