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FLASH GENE
Symbol TDRD12 contributors: mct - updated : 25-03-2014
HGNC name tudor domain containing 12
HGNC id 25044
Location 19q13.11      Physical location : 33.210.678 - 33.281.713
Synonym name
  • putative ATP-dependent RNA helicase TDRD12
  • ES cell associated transcript 8
  • Synonym symbol(s) ECAT8, FLJ13072
    EC.number 3.6.4.13
    DNA
    TYPE functioning gene
    STRUCTURE 71.04 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1617 - 395 - 2013 24067652
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary    Mus musculus
     male systemtestis    Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a central helicase and two flanking tudor domains, that are likely to engage PIWIL2 in a methylation-independent manner
  • along with a C-terminal CS domain
  • HOMOLOGY
    Homologene
    FAMILY TDRD family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • role for the multidomain protein in mediating complex formation with other participants during secondary PIWI-interacting RNAs (piRNAs)biogenesis
  • essential role of TDRD12 for normal spermatogenesis
  • is essential for germ cells in maintaining control over endogenous retrotransposons
  • TDRD1, TDRKH, TDRD9 and TDRD12, function in piRNA biogenesis and retrotransposon silencing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct interaction between PIWIL2 and TDRD12 (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS