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FLASH GENE
Symbol TDRD1 contributors: mct - updated : 11-03-2011
HGNC name tudor domain containing 1
HGNC id 11712
Location 10q25.3      Physical location : 115.939.028 - 115.992.063
Synonym name
  • cancer/testis antigen 41.1
  • Synonym symbol(s) CT41.1, FLJ21082, MTR-1
    DNA
    TYPE functioning gene
    STRUCTURE 53.03 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA1560 10q25.3 glycerol 3-phosphate acyltransferase, mitochondrial TECTB 10q25-q26 tectorin beta LOC390003 10 similar to guanylyl cyclase with kinase-like domain, soluble FACL5 10q25.1-q25.2 fatty-acid-Coenzyme A ligase, long-chain 5 ZDHHC6 10q26.11 zinc finger, DHHC domain containing 6 VTI1A 10q26.11 vesicle transport through interaction with t-SNAREs homolog 1A (yeast) TCF7L2 10q25.3 transcription factor 7-like 2 (T-cell specific, HMG-box) FLJ23556 10q26.11 hypothetical protein FLJ23556 LOC390004 10 similar to peptidylprolyl isomerase E (cyclophilin E) HABP2 10q26.11 hyaluronan binding protein 2 NRAP 10q23-q26 nebulin-related anchoring protein CASP7 10q25.1-q25.2 caspase 7, apoptosis-related cysteine protease FLJ23537 10q26.11 hypothetical protein FLJ23537 DCLRE1A 10q25.1 DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) FLJ25621 10q26.11 FLJ25621 protein FLJ20147 10q26.11 hypothetical protein FLJ20147 ADRB1 10q24.3 adrenergic, beta-1-, receptor FLJ10188 10q26.11 CTCL tumor antigen L14-2 TDRD1 10q24.1-q25.3 tudor domain containing 1 AMACO 10q26.11 A-domain containing protein similar to matrilin and collagen STK6LP 10q25-q26 serine/threonine kinase 6-like pseudogene LOC390005 10 similar to AMACO FLJ14564 10q26.11 hypothetical protein FLJ14564 ABLIM1 10q25 actin binding LIM protein 1 LOC390006 10 similar to peptidylprolyl isomerase A (cyclophilin A) KIAA1600 10q26.11 KIAA1600 protein TRUB1 10q26.11 TruB pseudouridine (psi) synthase homolog 1 (E. coli) KIAA0534 10q26 KIAA0534 protein GFRA1 10q26 GDNF family receptor alpha 1 MGC35062 10q26.11-q26.12 Similar to RIKEN cDNA 1700011F14 gene LOC119548 10q26.12 hypothetical protein LOC119548 PNLIP 10q24-q26 pancreatic lipase PNLIPRP1 10q26.12 pancreatic lipase-related protein 1 PNLIPRP2 10q26.12 pancreatic lipase-related protein 2 MGC33547 10q26.12 hypothetical protein MGC33547 HSPA12A  heat shock 70kDa protein 12A LOC387712 10 similar to RIKEN cDNA 6430537H07 gene KIAA1598 10q26.12 KIAA1598 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 4510 - 1189 - 2001 11279525
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid Homo sapiens
    Reproductivespermatocyte Homo sapiens
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region containing the myeloid Nervy DEAF-1 (MYND) domain, for interaction with PIWIL2
  • four tudor domains
  • one KH domain
  • HOMOLOGY
    interspecies ortholog to murine Tdrd1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    text
  • present in the cytoplasm of prospermatogonia, spermatocytes, and round spermatids, and predominantly localizes to chromatoid bodies
  • basic FUNCTION
  • binding to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane
  • potentially functions in assembling snRNPs into cytoplasmic granules in germ cells
  • with TDRD6, and RNF17, play evolutionarily conserved roles in germinal granule/nuage formation and germ cell specification and differentiation
  • TDRD1, TDRKH, TDRD9 and TDRD12, function in piRNA biogenesis and retrotransposon silencing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • formation of complexes between PIWIL1, PIWIL2 and TDRD1 is critical for the integrated subcellular localizations of these proteins, and is presumably essential for spermatogenesis
  • interacting with PIWIL2, that positively regulates the expression of the TDRD1 mRNA
  • TDRD1 is the first identified upregulated direct ERG target gene that is strongly associated with ERG overexpression in primary prostate cancer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS