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FLASH GENE
Symbol TDO2 contributors: - updated : 25-07-2006
HGNC name tryptophan 2,3-dioxygenase
HGNC id 11708
Location 4q31-q32      Physical location : 156.824.846 - 156.841.550
Synonym symbol(s) TPH2, TRPO, TDO
EC.number 1.13.11.11
DNA
TYPE functioning gene
STRUCTURE 16.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Endocrineneuroendocrinepituitary  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
YY1 transcription factor binding site
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION catalyzing the oxidation of L-tryptophan to formylkynurenine and controling the physiological flux of tryptophan into both the serotonergic and kynureninic pathways
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
tryptophan catabolism
a component four noncovalently bound subunits of equivalent mass and contains two heme moieties per molecule
INTERACTION
DNA
RNA
small molecule other,
binds 2 heme groups per tetramer(protoheme IV)
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
reduced placental indoleamine 2,3-dioxygenase activity causing dysregulation of the inflammatory response that is intrinsic to normal pregnancy and contributing to preeclampsia
Susceptibility to autism
Variant & Polymorphism
Candidate gene for alcoholism susceptibility
Marker
Therapy target
ANIMAL & CELL MODELS