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FLASH GENE
Symbol TCTEX1D4 contributors: mct - updated : 20/10/2008
HGNC name Tctex1 domain containing 4
HGNC id 32315
Location 1p34.1      Physical location : 45.271.589 - 45.272.957
Synonym name
  • Tctex2 beta
  • novel Tctex-1 family domain-containing protein
  • Synonym symbol(s) RP11-269F19.9
    DNA
    TYPE functioning gene
    STRUCTURE 1.37 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1278 - 221 - Meng (2008)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly Homo sapiens
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothvessel highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Reproductivespermatozoa Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • dynein light chain family
  • TCTEX1 dynein light chain family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text
  • PPP1CC co-localize with TCTEX1D4 in the microtubule organizing center (MTOC)
  • basic FUNCTION
  • had a profound inhibitory effect on TGF-beta signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • TCTEX1D4/PPP1CC complex appears to be involved in microtubule dynamics, sperm motility, acrosome reaction and in the regulation of the blood-testis barrier
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with different transforming growth factor-beta receptors
  • interacting with endoglin (some endoglin functions might be regulated and directed by its interaction with the cytoplasmic dynein light chain TCTEX1D4)
  • TCTEX1D4 interacts with the different spliced isoforms of PPP1CC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS