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FLASH GENE
Symbol TCN1 contributors: - updated : 16-03-2006
HGNC name transcobalamin I (vitamin B12 binding protein, R binder family)
HGNC id 11652
Location 11q11-q12      Physical location : 59.620.280 - 59.634.041
Synonym name haptocorrin
Synonym symbol(s) TC1, TCI
DNA
TYPE functioning gene
STRUCTURE 13.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
LOC390192 11 LOC390192 LOC219976 11q12.2 similar to FLJ00239 protein LOC390193 11 similar to olfactory receptor MOR215-1 LOC390194 11 similar to olfactory receptor MOR215-1 LOC390195 11 similar to Olfactory receptor 5AN1 LOC390196 11 similar to seven transmembrane helix receptor LOC219981 11q12.2 similar to Olfactory receptor 5A2 LOC219982 11q12.2 similar to Olfactory receptor 5A1 (OST181) LOC219983 11q12.2 similar to Olfactory receptor 4D6 LOC390197 11 similar to seven transmembrane helix receptor LOC390198 11 similar to seven transmembrane helix receptor LOC219986 11q12.2 similar to seven transmembrane helix receptor LOC390199 11 similar to Olfactory receptor 4D9 LOC390200 11 similar to olfactory receptor MOR239-1 OSBP 11q12.2 oxysterol binding protein FLJ36874 11q12.2 hypothetical protein FLJ36874 LOC390201 11 similar to seven transmembrane helix receptor LOC390202 11 similar to olfactory receptor GA_x6K02T2RE5P-2207258-2206302 STX3A 11q12.1 syntaxin 3A MRPL16 11q12-q13.1 mitochondrial ribosomal protein L16 GIF 11q12.2 gastric intrinsic factor (vitamin B synthesis) TCN1 11q11-q12 transcobalamin I (vitamin B12 binding protein, R binder family) LOC390203 11 similar to hypothetical protein FLJ13352 LOC255649 11q12.2 hypothetical LOC255649 FLJ36198 11q12.2 hypothetical protein FLJ36198 MS4A3 11q12 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) MS4A2 11q12.2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) MS4A6A 11q12.1 membrane-spanning 4-domains, subfamily A, member 6A LOC390204 11 similar to membrane-spanning 4-domains, subfamily A, member 4 isoform b; membrane-spanning 4-domains, subfamily A, member 4A; four-span transmembrane protein; Fc epsilon receptor beta subunit homolog
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland    
 stomach   highly
Endocrinepancreas   moderately
 parathyroid   moderately
Reproductivefemale systembreastmammary gland moderately
 male systemprostate  moderately
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil
cell lineage
cell lines
fluid/secretion milk, saliva, tears, bile, plasma
at STAGE
physiological period
Text later stages of myeloid development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a signal peptide
conjugated GlycoP
isoforms Precursor a signal peptide from the 1st to the 23th aa
HOMOLOGY
Homologene
FAMILY
  • vitamin B12-binding protein family
  • eukaryotic cobalamin transport protein family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text secreted, secondary granules
    basic FUNCTION facilitating the transport of cobalamin into cells
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport , cellular trafficking transport
    text cobalamin transport
    PATHWAY
    metabolism
    signaling
    a component major constituent ofsecondary granules in neutrophils
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Co2+
    protein
    cell & other vitamin B12
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS