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FLASH GENE
Symbol TCL6 contributors: - updated : 04-05-2004
HGNC name T-cell leukemia/lymphoma 6
HGNC id 13463
Location 14q32.1      Physical location : 96.117.514 - 96.139.789
Synonym name TCL1 neighboring gene 2
Synonym symbol(s) TCL6e1,TNG1,TNG2
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
text transcribed in the same direction than TML1
STRUCTURE 41.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
regionally located 7kb upstream of TCL1B (TML1),centromeric to TML1 and transcribed in the same direction
RNA
TRANSCRIPTS type messenger
text other transcripts also including transcripts spliced with TCL1B such as ORF72
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 3807 15.9 141 kidney, cytoplasmic Hallas,Saitou
  • lacking exons 1 through 4
  • containing exons 5a,6a,7a,8a and 9
  • same 141-amino acid open reading frame as variants a2 and a3
  • - splicing 4263 15.9 141 kidney, cytoplasmic Hallas,Saitou
  • lacking exons 1 through 4
  • containing exons 5a,6a,8a and 12
  • same 141-amino acid open reading frame as variants a1 and a3
  • - splicing 3430 15.9 141 kidney, cytoplasmic Hallas,Saitou
  • lacking exons 1 through 4
  • containing exons 5a,6b,6d,7a,8a and 12
  • same 141-amino acid open reading frame as variants a1 and a2
  • - splicing 3336 13.9 119 placenta, nuclear Hallas,Saitou
  • containing exons 1,2a,3,4a,6d,7a,8a and 10a
  • a 119-amino acid open reading frame that is unlike variant a1,a2,a3,b1 and d1
  • - splicing 2221 18.5 163 placenta, nuclear Hallas,Saitou
  • containing exons 1,2a,3,5c,6d,7a,8a and 9
  • a 163-amino acid open reading frame unlike variants a1 a2 a3 b1 or c1
  • - splicing 3692 11.6 105 placenta, nuclear Hallas,Saitou
  • lacking exons 1 through 4
  • contains exons 5a,6d,7a,8a and 10a
  • a 105-amino acid open reading frame unlike variants a1,a2,a3,c1 or d1
  • - splicing 3532 15.9 141 - Saitou
    - splicing 3599 15.9 141 - Saitou
    - splicing 3240 11.6 105 - Saitou
    - splicing 3144 11.6 105 - Saitou
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Reproductivemale systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines tumor cells
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION playing a role which is similar to or complementary to other T-cell leukemia/lymphoma proteins during early embrogenesis
    CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text potentially involved in leukemogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to TCL1A,TCL1B
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate for leukemogenesis
    Marker
    Therapy target
    ANIMAL & CELL MODELS