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FLASH GENE

Symbol

TCL1A

contributors: mct/pgu - updated : 01-10-2013

HGNC name	T-cell leukemia/lymphoma 1A
HGNC id	11648

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	TCL1A T-CLL chronic lymphocytic leukemia
Location	14q32.13      Physical location : 96.176.304 - 96.180.533
Synonym name	T-cell lymphoma 1
	oncogene TCL1
	protein p14 TCL1
Synonym symbol(s)	TCL1

DNA

TYPE	anonymous DNA segment
STRUCTURE	4.23 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (TATA box)
text structure	5'-TCL1 promoter region contains a TATA box with cis-regulatory elements for Nur77/NGFI-B (nerve growth factor-responsive element (NBRE), CCAAGGTCA), NFkappaB, and fork head transcription factor (nerve growth factor-responsive element being a negative regulatory element)

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001098725 4 - 1405 NP_001092195 - 114 - 2000 10983986 NM_021966 4 - 1410 NP_068801 - 114 - 2000 10983986

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node           tonsils         Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell Homo sapiens

cell lineage	normally in pre-B cells and immature IgM expressing B cells and in early T cell progenitors with very low levels in bone marrow and peripheral lymphocytes
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , heteromer , dimer , trimer

HOMOLOGY

intraspecies

homolog to MTCP1

Homologene

FAMILY

TC11 family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic,microsome
	intracellular,nucleus
text	localizes in both nucleus and cytoplasm

basic FUNCTION	stabilizing the mitochondrial transmembrane potential and enhancing cell proliferation and survival
	AKT kinase coactivator
	inhibits DNA methylation, in aggressive B-cell chronic lymphocytic leukemia
	is naturally processed and presented on the surface of lymphoma cells for recognition by cytotoxic T cells

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

AKT1/TCL1A multimeric complex activating AKT

INTERACTION

DNA

RNA

small molecule

protein	coactivator of AKT
	physically interacts with c-Jun, JunB, and c-Fos and inhibits AP-1 transcriptional activity
	binds specifically and directly to the ankyrin domain of IKBKB, the inhibitor of the NF-kappaB transcription factors
	role of TCL1A in PTPROt suppression, important in the pathogenesis ofchronic lymphocytic leukemia (CLL)
	physically interacts with DNA methylthansferases DNMT3A and DNMT3B
	TCL1A and ATM functionally cooperate to modulate similar apoptosis-related cellular pathways
	functional interaction between TCL1A and HSPA4 and TCL1A is a novel HSPA4 client protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

TCL1A

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   dysregulated in T cell lymphoma tumoral     --over   in mature B cell lymphoma tumoral     --over   in T-cell prolymphocytic leukemia tumoral     --over   causes B-CLL by directly enhancing NFKB activity and inhibiting AP-1 tumoral     --other   TCL1A dysregulation in B cells is responsible for the development of an aggressive form of chronic lymphocytic leukemia (CLL), the most common human leukemia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	diagnostic marker used in the differential diagnosis of splenic low-grade B-cell lymphoma
Therapy target
	System Type Disorder Pubmed cancer hemopathy   target for development of immunotherapeutic strategies against common B-cell lymphomas

ANIMAL & CELL MODELS