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FLASH GENE
Symbol TCHP contributors: mct/npt/pgu - updated : 18-11-2015
HGNC name trichoplein, keratin filament binding
HGNC id 28135
Location 12q24.11      Physical location : 110.338.078 - 110.355.873
Synonym name
  • trichoplein
  • mitostatin
  • Synonym symbol(s) MGC10854, TPMs
    DNA
    TYPE functioning gene
    STRUCTURE 17.79 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3111 - 498 - 2005 15731013
    13 - 3172 - 498 - 2005 15731013
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  highly
     liver   highly
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunelymph node   highly
    Reproductivemale systemtestis  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a rodlike tail sequence highly repetitive: an heptapeptide repeat pattern characteristic of alpha-helical coiled coils
  • a plectin homology domain, suggesting that the mitochondrial plectin could mediate its association with mitochondria
  • HOMOLOGY
    interspecies homolog to murine Tchp (78.1pc)
    homolog to rattus Tchp (75.7pc)
    intraspecies homolog to to trichohyalin, plectin and myosin heavy chain
    Homologene
    FAMILY
  • TCHP family
  • CATEGORY structural protein , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus
    text
  • colocalizing with KRT8 and KRT18 at the apical cortical membrane and with desmoplakin in epithelial cells
  • localized at the interface between mitochondria and ER
  • disappeared from the basal body in quiescent cells, whereas it localized to mother and daughter centrioles in proliferating cells
  • concentrated at the subdistal to medial zone of both mother and daughter centrioles
  • localized on keratin intermediate filaments and desmosomes in well-differentiated, non-dividing epithelia
  • basic FUNCTION
  • keratin-binding protein that may be involved in the organization of the apical network of keratin filaments and desmosomes in simple epithelial cells
  • required for protein transport from the ER to the Golgi complex
  • inhibiting cell growth and colony formation and enhancing the apoptotic response to various apoptotic stimuli
  • may act as a capping or branching protein for keratin filaments in the cell periphery
  • keratin-binding protein that partly colocalizes with mitochondria and is often downregulated in epithelial cancers
  • a new regulator of mitochondria-ER juxtaposition
  • requires MFN2 to modulate mitochondrial shape and tethering
  • role as a negative modulator of ER-mitochondria juxtaposition and extends the evidence supporting the importance of inter-organellar juxtaposition in cell
  • has a major function in the correct localization of the centrosomal protein ninein in epithelial and non-epithelial cells
  • has a crucial role in MT-anchoring activity at the centrosome in proliferating cells, probably through its complex formation with ODF2 and NIN
  • negatively affects cell growth, induces cell death and regulates the expression and activation levels of HSPB1
  • may acts as a tumor suppressor gene in prostate cancer
  • controlled AURKA activation at the centrioles predominantly in G1 phase
  • suppression of primary cilia assembly by trichoplein required its ability not only to localize to centrioles but also to bind and activate AURKA
  • decorin-induced tumor suppressor gene, and is a key regulator of tumor cell mitophagy and angiostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    TCHP-AURKA pathway is required for G1 progression through a key role in the continuous suppression of primary cilia assembly
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KRT8/KRT18-binding protein
  • interacted significantly with KRT16 and KRT18, and to some extent with KRT5, KRT6a, KRT8 and KRT14
  • new mitochondria-associated membrane protein interacting with MFN2 to regulate mitochondrial morphology and tethering with the ER
  • TCHP binds the centrosomal proteins ODF2 and NIN, which are localized at the distal to subdistal ends of the mother centriole
  • rapid and dynamic interplay between PPARGC1A and the decorin-induced tumor suppressor gene, TCHP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly reduced in primary bladder and breast tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS