SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,intermed filament
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| intracellular,nucleus
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text
| colocalizing with KRT8 and KRT18 at the apical cortical membrane and with desmoplakin in epithelial cells |
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localized at the interface between mitochondria and ER |
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disappeared from the basal body in quiescent cells, whereas it localized to mother and daughter centrioles in proliferating cells |
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concentrated at the subdistal to medial zone of both mother and daughter centrioles |
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localized on keratin intermediate filaments and desmosomes in well-differentiated, non-dividing epithelia |
basic FUNCTION
| keratin-binding protein that may be involved in the organization of the apical network of keratin filaments and desmosomes in simple epithelial cells |
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required for protein transport from the ER to the Golgi complex |
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inhibiting cell growth and colony formation and enhancing the apoptotic response to various apoptotic stimuli |
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may act as a capping or branching protein for keratin filaments in the cell periphery |
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keratin-binding protein that partly colocalizes with mitochondria and is often downregulated in epithelial cancers |
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a new regulator of mitochondria-ER juxtaposition |
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requires MFN2 to modulate mitochondrial shape and tethering |
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role as a negative modulator of ER-mitochondria juxtaposition and extends the evidence supporting the importance of inter-organellar juxtaposition in cell |
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has a major function in the correct localization of the centrosomal protein ninein in epithelial and non-epithelial cells |
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has a crucial role in MT-anchoring activity at the centrosome in proliferating cells, probably through its complex formation with ODF2 and NIN |
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negatively affects cell growth, induces cell death and regulates the expression and activation levels of HSPB1 |
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may acts as a tumor suppressor gene in prostate cancer |
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controlled AURKA activation at the centrioles predominantly in G1 phase |
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suppression of primary cilia assembly by trichoplein required its ability not only to localize to centrioles but also to bind and activate AURKA |
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decorin-induced tumor suppressor gene, and is a key regulator of tumor cell mitophagy and angiostasis |