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Symbol TCHHL1 contributors: mct - updated : 21-08-2013
HGNC name trichohyalin-like 1
HGNC id 31796
Location 1q21.3      Physical location : 152.056.619 - 152.061.540
Synonym name
  • S100 calcium binding protein A17
  • basalin
  • intermediate filament-associated protein
  • Synonym symbol(s) S100A17, THHL1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 4.92 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3603 - 904 - 2013 23376073
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Skin/Tegumentskin     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermisstratum basale  Homo sapiensAdult
    Epithelialbarrier liningepidermis   Homo sapiensFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumenthair follicle cell Homo sapiensAdult
    Skin/Tegumentkeratinocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • EF-hand domain in the N-terminus,
  • one trans-membrane domain
  • a nuclear localization signal
  • HOMOLOGY
    Homologene
    FAMILY
  • EF-hand superfamily
  • fused-type S100 protein gene family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nuclear envelope
    text
  • clearly observed in the basal layer of the normal epidermis
  • might be associated with nuclear envelopes, which separate a cell genetic material from the surrounding cytoplasm
  • basic FUNCTION
  • might potentially play important roles in the proliferation of keratinocytes, similar to S100A11
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS