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FLASH GENE
Symbol TCF7L1 contributors: mct - updated : 19-04-2014
HGNC name transcription factor 7-like 1 (T-cell specific, HMG-box)
HGNC id 11640
Location 2p11.2      Physical location : 85.360.733 - 85.537.504
Synonym name
  • HMG-box transcription factor TCF-3
  • T-cell specific, HMG-box
    • Synonym symbol(s) TCF3, TCF-3
    DNA
    TYPE functioning gene
    STRUCTURE 176.93 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2932 - 588 - 2004 14668413
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Reproductivefemale systembreastmammary gland  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell
    Skin/Tegumenthair follicle cell
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a HMG box
  • a beta-catenin binding domain
  • a nuclear localization signal
  • a gly-rich domain
  • a pro-rich domain
    • HOMOLOGY
    interspecies ortholog to murine Tcf3
    ortholog to rattus Tcf3_predicted
    intraspecies homolog to TCF7L2
    Homologene
    FAMILY TCF/LEF family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the regulation of transcription in a DNA-dependent manner
  • repressor activity in absence of CTNNB1
  • activator activity in its presence
  • down-regulates NQO1, resulting in a mytomycin C resistance
  • necessary for the terminal differenciation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis
  • unique requirement for TCF7L1 repressor function in restricting induction of the anterior-posterior axis
  • in the absence of Wnt signals, may function in skin stem cells to maintain an undifferentiated state and, through Wnt signaling, directs these cells along the hair lineage
  • important role in modulating the appropriate level of gene transcription in ESCs and during embryonic development
  • cell-intrinsic inhibitor of pluripotent cell self-renewal that functions by limiting steady-state levels of self-renewal factors
  • transcriptional repressor that has been implicated in Wnt signaling and plays key roles in embryonic axis specification and stem cell differentiation
  • transcriptional hub coordinating cell–cell contact with the transcriptional repression required for adipogenic competency
  • represses structure-related genes during adipogenesis
  • adipogenic competency factor that uniquely determines adipogenic fate through cell structure organization required for adipocyte gene activation
    • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binds the armadillo repeat of CTNNB1 and forms a stable complex
  • TCF7L1-mediated control of NANOG levels allows stem cells to balance the creation of lineage-committed and undifferentiated cells
  • binds and directly regulates the expression of cell structure genes
  • indirectly regulates PPARG enhancer in early adipogenesis
  • TCF7L1-mediated cell structure changes contribute to PPARG2 induction, providing synchrony between adipogenic commitment and terminal differentiation
  • DGCR8 is a direct interactor of TCF7L1 mRNA, a core component of the pluripotency network
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    occasionally, in primary gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Tcf7l1 null mice are early embryonic lethal