Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TCF21 contributors: mct - updated : 06-07-2020
HGNC name transcription factor 21
HGNC id 11632
Location 6q23.2      Physical location : 134.210.258 - 134.216.675
Synonym name
  • pericardin, capsulin
  • podocyte expressed 1
  • class A basic helix-loop-helix protein 23
  • epicardin
    • Synonym symbol(s) POD1, bHLHa23
    DNA
    TYPE functioning gene
    STRUCTURE 6.42 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3216 - 179 - 2019 31014396
    2 - 1280 - 179 - 2019 31014396
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Reproductivemale systemtestis   
    Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Membrane    
    Membraneserouspericardiium  
    Muscularstriatumcardiac  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinarypodocyte Homo sapiensAdult
    Urinarypodocyte Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text mesenchymal and glomerular epithelial cells in the developing kidney,placenta,mesoderm
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		basic helix-loop-helix (HLH) motif protein
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Pod-1
    Homologene
    FAMILY basic helix-loop-helix family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • functions as a transcriptional repressor to regulate proepicardial cell specification and the correct formation of a mature epithelial epicardium
  • critical role for TCF21 in the differentiation and maintenance of podocytes
  • TCF21 may affect coronary artery disease risk through interaction with other disease associated loci
  • TCF21 functions as a tumor suppressor in esophageal squamous cell carcinoma (ESCC) progression
  • in contrast to TCF21 which is protective toward coronary artery disease (CAD), SMAD3 expression in human coronary artery smooth muscle cells (HCASMC) was shown to be directly correlated with disease risk
  • has distinct roles in the cap mesenchyme and stromal mesenchyme compartments during kidney development, suggesting that TCF21 regulates key molecular pathways required for branching morphogenesis
  • TCF21 suppresses in vivo tumor-associated angiogenesis
  • TCF21 promotes the transcription of LPL by directly binding to the E-box motif in the LPL promoter
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text embryonic development, mesoderm development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to E-box (5'-CANNTG-3')
    RNA
    small molecule
    protein
  • e12 and e47
  • SRY acts directly on the TCF21 promoter to in part initiate a cascade of events associated with Sertoli cell differentiation and embryonic testis development
  • promotes proinflammatory IL6 expression and extracellular matrix remodeling in visceral adipose stem cells
  • TCF21 is a novel regulator of preadipocyte differentiation, in part by directly promoting LPL expression
  • TCF21 blocks MYOCD and SRF association by direct TCF21-MYOCD interaction in smooth muscle cell differentiation
    • cell & other
    REGULATION
    Other autophagy may also play an important role in regulation TCF21 expression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in cholangiocarcinoma (CCA)
    tumoral     --over  
    by demethylation led to remarkable decreases of cell viability and invasion ability but an increase of cell apoptosis in lung cancer
    tumoral     --over  
    through promoter hypermethylation in colorectal cancer (CRC) development
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS