basic FUNCTION
| functions as a transcriptional repressor to regulate proepicardial cell specification and the correct formation of a mature epithelial epicardium ![](pubmed.jpg) |
|
critical role for TCF21 in the differentiation and maintenance of podocytes ![](pubmed.jpg) |
|
TCF21 may affect coronary artery disease risk through interaction with other disease associated loci ![](pubmed.jpg) |
|
TCF21 functions as a tumor suppressor in esophageal squamous cell carcinoma (ESCC) progression ![](pubmed.jpg) |
|
in contrast to TCF21 which is protective toward coronary artery disease (CAD), SMAD3 expression in human coronary artery smooth muscle cells (HCASMC) was shown to be directly correlated with disease risk ![](pubmed.jpg) |
|
has distinct roles in the cap mesenchyme and stromal mesenchyme compartments during kidney development, suggesting that TCF21 regulates key molecular pathways required for branching morphogenesis ![](pubmed.jpg) |
|
TCF21 suppresses in vivo tumor-associated angiogenesis ![](pubmed.jpg) |
|
TCF21 promotes the transcription of LPL by directly binding to the E-box motif in the LPL promoter ![](pubmed.jpg) |