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FLASH GENE
Symbol TCF20 contributors: - updated : 12-01-2007
HGNC name transcription factor 20 (AR1)
HGNC id 11631
Location 22q13.3      Physical location : 42.556.018 - 42.611.445
Synonym name
  • SPRE-binding protein
  • stromelysin-1 platelet-derived growth factor-responsive element binding protein
    • Synonym symbol(s) AR1, RP4-669P10.13, KIAA0292, SPBP
    DNA
    TYPE functioning gene
    STRUCTURE 55.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 7407 - 1960 - Gburcik
    - - 7279 - 1938 - Gburcik
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Nervousnervecranial nerve  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an atypical PHD domain functioning as a negative modulator of cofactor binding
  • a A.T hook DNA-binding domain
  • a PHD-type zinc finger
    • mono polymer homomer , dimer
    HOMOLOGY
    intraspecies homolog to Spbp,highly
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1
  • transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression
  • phosphoserine-specific repressor of activated ESR1, a DNA binding transactivation factor and coactivator of other transcription factors
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with RNF4 and JUN
  • stimulating the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting
    • a function as a coactivator
  • binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter
  • might not interact directly with DNA but with DNA-bound proteins
  • interacts with mating-type protein alpha2, HIRA and SLC13A4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS