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FLASH GENE
Symbol TCF20 contributors: - updated : 12-01-2007
HGNC name transcription factor 20 (AR1)
HGNC id 11631
Location 22q13.3      Physical location : 42.556.018 - 42.611.445
Synonym name
  • SPRE-binding protein
  • stromelysin-1 platelet-derived growth factor-responsive element binding protein
  • Synonym symbol(s) AR1, RP4-669P10.13, KIAA0292, SPBP
    DNA
    TYPE functioning gene
    STRUCTURE 55.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    RPC8 22q13.2 RNA polymerase III subunit RPC8 PIPPIN 22q13.2-q13.31 RNA-binding protein pippin PMM1 22q13.2 phosphomannomutase 1 D15Wsu75e 22q13.2 DNA segment, Chr 15, Wayne State University 75, expressed G22P1 22q13.1 thyroid autoantigen 70kDa (Ku antigen) NHP2L1 22q13.2-q13.1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) FLJ23584 22q13.2 hypothetical protein FLJ23584 HMG17L2 22q13.2 high-mobility group (nonhistone chromosomal) protein 17-like 2 MGC40042 22q13.2 hypothetical protein MGC40042 FLJ22349 22q13.2 hypothetical protein FLJ22349 SREBF2 22q13.2 sterol regulatory element binding transcription factor 2 TNFRSF13C 22q13.1-q13.31 tumor necrosis factor receptor superfamily, member 13C C22orf18 22q13.2-q13.31 chromosome 22 open reading frame 18 SEPT3 22q13.2 septin 3 MGC26816 22q13.31 hypothetical protein MGC26816 NAGA 22q13.2 N-acetylgalactosaminidase, alpha- LOC150368 22q13.31 hypothetical protein LOC150368 LOC91689 22q13.31 hypothetical gene supported by AL449243 NDUFA6 22q13.2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa LOC246785 22q13.2 PTD004 pseudogene CYP2D8P2 22q11.22-q11.23 cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2 CYP2D8P1 22q13.2-q13.31 cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 1 TCF20 22q13.3 transcription factor 20 (AR1) LOC388906 22 hypothetical gene supported by BC039496 LOC150371 22q13.31 hypothetical LOC150371 NFAM1 22q13.31 NFAT activation molecule 1 SERHL 22q13.2-q13.31 serine hydrolase-like CGI-96 22q13.2-q13.31 CGI-96 protein dJ222E13.1 22q13 kraken-like dJ222E13.2 22q13.31 similar to CGI-96 PDIP46 RNU12P 22 RNA, U12 small nuclear pseudogene DIA1 22q13.2 diaphorase (NADH) (cytochrome b-5 reductase)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 7407 - 1960 - Gburcik
    - - 7279 - 1938 - Gburcik
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Nervousnervecranial nerve  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an atypical PHD domain functioning as a negative modulator of cofactor binding
  • a A.T hook DNA-binding domain
  • a PHD-type zinc finger
  • mono polymer homomer , dimer
    HOMOLOGY
    intraspecies homolog to Spbp,highly
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1
  • transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression
  • phosphoserine-specific repressor of activated ESR1, a DNA binding transactivation factor and coactivator of other transcription factors
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with RNF4 and JUN
  • stimulating the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting
  • a function as a coactivator
  • binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter
  • might not interact directly with DNA but with DNA-bound proteins
  • interacts with mating-type protein alpha2, HIRA and SLC13A4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS