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FLASH GENE
Symbol TCF19 contributors: KTN/npt - updated : 21/11/2008
HGNC name transcription factor 19 (SC1)
HGNC id 11629
Location 6p21.33      Physical location : 2.422.153 - 31.131.991
Synonym name transcription factor SC1
Synonym symbol(s) SCI, SC1, SC1-1, SC1(TCF19)-6, SC1(TCF19)-7, SCI(TCF19)-4
DNA
TYPE functioning gene
STRUCTURE 5.69 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
KIAA1949 6p21.3 KIAA1949 protein NRM 6p21.31 nurim (nuclear envelope membrane protein) MDC1 6pter-p21.3 mediator of DNA damage checkpoint 1 OK/SW-cl.56 6p21.32 beta 5-tubulin FLOT1 6p21.3 flotillin 1 IER3 6p21.3 immediate early response 3 DDR1 6p21.3 discoidin domain receptor family, member 1 VARS2L 6p21.33 valyl-tRNA synthetase 2-like GTF2H4 6p21.3 general transcription factor IIH, polypeptide 4, 52kDa LOC389376 6 similar to GSGL541 DPCR1 6p21.32 similar to GSGL541 LOC389377 6 similar to KMQK697 C6orf15 6p21.3 chromosome 6 open reading frame 15 PSORS1C1 6p21.3 psoriasis susceptibility 1 candidate 1 CDSN 6p21.3 corneodesmosin PSORS1C2 6p21.3 psoriasis susceptibility 1 candidate 2 C6orf18 6p21.3 chromosome 6 open reading frame 18 TCF19 6p21.3 transcription factor 19 (SC1) POU5F1 6p21.31 POU domain, class 5, transcription factor 1 LOC253018 6p21.32 hypothetical protein LOC253018 LOC391911 6 similar to HLA-B-associated transcript 1A; HLA-B associated transcript 1A; HLA-B associated transcript 1; Nuclear RNA helicase HLA-C 6p21.3 major histocompatibility complex, class I, C HLA-B 6p21.3 major histocompatibility complex, class I, B MICA 6p21.3 MHC class I polypeptide-related sequence A HCP5 6p21.3 HLA complex P5 MICB 6p21.3 MHC class I polypeptide-related sequence B PPIP9 6p21.3 peptidylprolyl isomerase (cyclophilin) pseudogene 9 BAT1 6p21.33 HLA-B associated transcript 1 ATP6V1G2 6p21.3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 2 NFKBIL1 6p21.3 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 LTA 6p21.3 lymphotoxin alpha (TNF superfamily, member 1) TNF 6p21.3 tumor necrosis factor (TNF superfamily, member 2)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 splicing 3306 37.1 345 - -
4 splicing 3060 37.1 345 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestine   moderately
Endocrineadrenal gland   moderately
Lymphoid/Immunelymph node   moderately
 thymus   highly
Reproductivefemale systemuteruscervix moderately
 male systemprostate  moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately
cell lineage
cell lines
fluid/secretion moderately in blood and highly in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an FHA domain
  • a PHD-type zinc finger
  • HOMOLOGY
    interspecies homolog to dog TCF19 (85.5 pc)
    homolog to cow TCF19 (85.8 pc)
    homolog to rattus Tcf119 (81.8 pc)
    homolog to murine Tcf19 (80.5 pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    Other growth regulated
    phosphorylated upon DNA damage, probably by ATM or ATR
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS