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FLASH GENE
Symbol TCERG1 contributors: mct - updated : 06-02-2014
HGNC name transcription elongation regulator 1
HGNC id 15630
Location 5q32      Physical location : 145.826.872 - 145.891.068
Synonym name
  • transcription factor CA150
  • TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD
  • transcription elongation regulator 1 (CA150)
  • weakly similar to similar to a short region of rat GAP-associated
  • Synonym symbol(s) CA150, TAF2S, MGC133200, Urn1
    DNA
    TYPE functioning gene
    STRUCTURE 64.20 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ASSP10 5q13-q23 argininosuccinate synthetase pseudogene 10 LOC391837 5 similar to transient receptor potential cation channel, subfamily C, member 6; transient receptor potential channel 6 MGC21644 5q32 hypothetical protein MGC21644 FLJ23654 5q32 hypothetical protein FLJ23654 LOC153770 5q32 similar to protein related with psoriasis LARS 5q32 leucyl-tRNA synthetase KIAA1311 5q32 KIAA1311 protein POU4F3 5q31-q32 POU domain, class 4, transcription factor 3 TCERG1 5q31 transcription elongation regulator 1 (CA150) GPR151 5q32 G protein-coupled receptor 151 PPP2R2B 5q31-q33 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform MGC22688 5q32 hypothetical protein MGC22688 DPYSL3 5q32 dihydropyrimidinase-like 3 KIAA0555 5q32 dihydropyrimidinase-like 3 SPINK1 5q31 serine protease inhibitor, Kazal type 1 LOC391838 5 similar to low affinity N-formyl peptide receptor SCGB3A2 5q32 secretoglobin, family 3A, member 2 LOC389336 5 similar to AVLV472 LOC391839 5 similar to elongation factor 1 gamma SPINK5 5q32 serine protease inhibitor, Kazal type, 5 LOC340060 5q33.1 similar to alpha-5 collagen ECG2 5q33.1 similar to alpha-5 collagen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 4233 - 1098 - 2006 16782886
  • isoform 1
  • 21 - 4170 - 1077 - 2006 16782886
  • isoform 2
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal insertion containing an imperfect Gln-Ala repeat, and three N-terminal WW domains
  • six consecutive FF domains
  • C-terminal three FF domains (FF4-6) (FF4 and FF5 domains target proteins to the periphery of speckles)
  • HOMOLOGY
    interspecies homolog to murine Tcerg1 (97.8pc)
    homolog to rattus Tcerg1 (97.8pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • transcriptional modulator activity
  • required to assemble transcription/splicing complexes, which may be involved in the coupling of those processes
  • modulates human immunodeficiency virus type 1 gene transcription
  • could mediate the recruitment of transcription and splicing factors to actively transcribing RNA polymerase II
  • play a role in mRNA processing and can couples transcription and processing
  • involved in splicing of cellular mRNAs
  • factor implicated in interactions with the spliceosome as a coupler of transcription and splicing
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with RNA polymerase II and with HD
  • interacts with the splicing factor SF1 and with the phosphorylated C-terminal repeat domain (CTD) of RNA polymerase II through its WW and FF domains, respectively
  • binding to UBE2I and being sumoylated (Sanchez-Alvarez 2010)
  • functions as an inhibitor of CEBPA rather than a transcriptional co-repressor and inhibits CEBPA activity by keeping it retained in inactive, pericentromeric heterochromatin
  • inhibits RNA polymerase II elongation through these WW and FF domains, and interacts with pre-mRNA splicing factors such as SF1, U2 snRNP and U2AF
  • regulates alternative splicing of the apoptosis gene BCL2L1 in a promoter-dependent manner
  • modulates the elongation rate of RNA polymerase II to relieve pausing, thereby activating the proapoptotic Bcl-x(S) 5 prime splice site
  • specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the C-terminal domain repeat
  • cell & other
  • Tkt-activated HIV type 1
  • REGULATION
    Other negatively regulated at transcriptional activity level by sumoylation (Sanchez-Alvarez 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Huntington brain
    Susceptibility to Huntington disease (HD)
    Variant & Polymorphism repeat polymorphism may contribute to age onset variability in HD
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS