Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
Symbol TCERG1 contributors: mct - updated : 06-02-2014
HGNC name transcription elongation regulator 1
HGNC id 15630
Location 5q32      Physical location : 145.826.872 - 145.891.068
Synonym name
  • transcription factor CA150
  • TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD
  • transcription elongation regulator 1 (CA150)
  • weakly similar to similar to a short region of rat GAP-associated
  • Synonym symbol(s) CA150, TAF2S, MGC133200, Urn1
    TYPE functioning gene
    STRUCTURE 64.20 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ASSP10 5q13-q23 argininosuccinate synthetase pseudogene 10 LOC391837 5 similar to transient receptor potential cation channel, subfamily C, member 6; transient receptor potential channel 6 MGC21644 5q32 hypothetical protein MGC21644 FLJ23654 5q32 hypothetical protein FLJ23654 LOC153770 5q32 similar to protein related with psoriasis LARS 5q32 leucyl-tRNA synthetase KIAA1311 5q32 KIAA1311 protein POU4F3 5q31-q32 POU domain, class 4, transcription factor 3 TCERG1 5q31 transcription elongation regulator 1 (CA150) GPR151 5q32 G protein-coupled receptor 151 PPP2R2B 5q31-q33 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform MGC22688 5q32 hypothetical protein MGC22688 DPYSL3 5q32 dihydropyrimidinase-like 3 KIAA0555 5q32 dihydropyrimidinase-like 3 SPINK1 5q31 serine protease inhibitor, Kazal type 1 LOC391838 5 similar to low affinity N-formyl peptide receptor SCGB3A2 5q32 secretoglobin, family 3A, member 2 LOC389336 5 similar to AVLV472 LOC391839 5 similar to elongation factor 1 gamma SPINK5 5q32 serine protease inhibitor, Kazal type, 5 LOC340060 5q33.1 similar to alpha-5 collagen ECG2 5q33.1 similar to alpha-5 collagen
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 4233 - 1098 - 2006 16782886
  • isoform 1
  • 21 - 4170 - 1077 - 2006 16782886
  • isoform 2
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   highly
    cell lineage
    cell lines
    at STAGE
  • N terminal insertion containing an imperfect Gln-Ala repeat, and three N-terminal WW domains
  • six consecutive FF domains
  • C-terminal three FF domains (FF4-6) (FF4 and FF5 domains target proteins to the periphery of speckles)
    interspecies homolog to murine Tcerg1 (97.8pc)
    homolog to rattus Tcerg1 (97.8pc)
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • transcriptional modulator activity
  • required to assemble transcription/splicing complexes, which may be involved in the coupling of those processes
  • modulates human immunodeficiency virus type 1 gene transcription
  • could mediate the recruitment of transcription and splicing factors to actively transcribing RNA polymerase II
  • play a role in mRNA processing and can couples transcription and processing
  • involved in splicing of cellular mRNAs
  • factor implicated in interactions with the spliceosome as a coupler of transcription and splicing
  • CELLULAR PROCESS nucleotide, transcription, regulation
    a component
    small molecule
  • associating with RNA polymerase II and with HD
  • interacts with the splicing factor SF1 and with the phosphorylated C-terminal repeat domain (CTD) of RNA polymerase II through its WW and FF domains, respectively
  • binding to UBE2I and being sumoylated (Sanchez-Alvarez 2010)
  • functions as an inhibitor of CEBPA rather than a transcriptional co-repressor and inhibits CEBPA activity by keeping it retained in inactive, pericentromeric heterochromatin
  • inhibits RNA polymerase II elongation through these WW and FF domains, and interacts with pre-mRNA splicing factors such as SF1, U2 snRNP and U2AF
  • regulates alternative splicing of the apoptosis gene BCL2L1 in a promoter-dependent manner
  • modulates the elongation rate of RNA polymerase II to relieve pausing, thereby activating the proapoptotic Bcl-x(S) 5 prime splice site
  • specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the C-terminal domain repeat
  • cell & other
  • Tkt-activated HIV type 1
    Other negatively regulated at transcriptional activity level by sumoylation (Sanchez-Alvarez 2010)
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Huntington brain
    Susceptibility to Huntington disease (HD)
    Variant & Polymorphism repeat polymorphism may contribute to age onset variability in HD
    Candidate gene
    Therapy target