basic FUNCTION
| cell death regulatory protein frequently inactivated in ovarian cancers, and that may function as a tumor suppressor |
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may be involved in transcriptional regulation |
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may restrict ovarian epithelial cells transformation by limiting Myc activity (Chien 2008) |
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promotes anchorage-independent growth and modulates Myc activity in ovarian surface epithelial cells |
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negatively regulates NF-KappaB signaling at the basal level by modulating transcriptional activity of NF-KappaB on its target gene promoters, potentially providing a novel mechanism by which NF-KappaB activity may be deregulated in ovarian cancer cells |
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putative tumor suppressor gene, negatively regulates NF-kappaB pathway |
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induce apoptosis in ovarian cancer cells, negatively regulate MYC activity, suppress nuclear factor (NFKB1) binding to its target DNA sequence, suggesting that TCEAL7 behaves as a tumor suppressor |