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FLASH GENE
Symbol TCEAL7 contributors: mct - updated : 29-03-2020
HGNC name transcription elongation factor A (SII)-like 7
HGNC id 28336
Location Xq22.2      Physical location : 102.585.113 - 102.587.251
Synonym name TCEA-like protein 7
Synonym symbol(s) MGC23947, MPMGp800C04260Q003, WEX5
DNA
TYPE functioning gene
STRUCTURE 2.14 kb     3 Exon(s)
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
text structure
  • TCEAL7 promoter revealed evolutionarily conserved E-box motifs within upstream fragment that were essential for promoter activity
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1162 - 100 - 2010 20454512
    3 - 1152 - 100 - 2010 20454512
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Nervousnervecranial nerve  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • TFS-II family
  • TFA subfamily
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • cell death regulatory protein frequently inactivated in ovarian cancers, and that may function as a tumor suppressor
  • may be involved in transcriptional regulation
  • may restrict ovarian epithelial cells transformation by limiting Myc activity (Chien 2008)
  • promotes anchorage-independent growth and modulates Myc activity in ovarian surface epithelial cells
  • negatively regulates NF-KappaB signaling at the basal level by modulating transcriptional activity of NF-KappaB on its target gene promoters, potentially providing a novel mechanism by which NF-KappaB activity may be deregulated in ovarian cancer cells
  • putative tumor suppressor gene, negatively regulates NF-kappaB pathway
  • induce apoptosis in ovarian cancer cells, negatively regulate MYC activity, suppress nuclear factor (NFKB1) binding to its target DNA sequence, suggesting that TCEAL7 behaves as a tumor suppressor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • represses cellular transformation by negatively modulating MYC and NFKB1
  • myogenic regulatory factors transactivate the TCEAL7 gene and modulate muscle differentiation
  • TCEAL7 inhibition of MYC activity in alternative lengthening of telomeres regulates TERT expression
  • TCEAL7 regulates CCND1 expression through MYC-binding E-box sequences
  • TCEAL7 levels negatively correlated with increased CCND1 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    by methylation in ovarian cancer, epigenetically down-regulated in the majority of cases
    tumoral     --low  
    in non-small cell lung cancer tumor tissues
    Susceptibility
    Variant & Polymorphism SNP
  • polymorphisms may play a role in the development of invasive serous ovarian cancers (Peedicayil 2009)
  • Candidate gene
  • might serve as a candidate tumor suppressor in gastric carcinogenesis
  • Marker
  • might serve as a potential prognostic biomarker in gastric carcinogenesis
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    may function as a useful target for new therapeutic interventions against gastric adenocarcinoma
    ANIMAL & CELL MODELS