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FLASH GENE
Symbol TCEA1 contributors: mct - updated : 23-01-2019
HGNC name transcription elongation factor A (SII), 1
HGNC id 11612
Location 8q11.23      Physical location : 54.879.116 - 54.935.008
Synonym name
  • epididymis secretory sperm binding protein
  • transcription factor IIS
  • Synonym symbol(s) GTF2S, TCEA, SII, TF2S, TFIIS
    DNA
    TYPE functioning gene
    STRUCTURE 55.89 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    cytosine-phosphate-guanine/HTF
    motif repetitive sequence   ALU
    text structure
  • two putative GC-box-type consensus sequences,two CCAAT-box consensus sequences and is bounded by an Alu sequence
  • MAPPING cloned Y linked   status provisional
    Physical map
    BTF3P1 8q11.22 basic transcription factor 3, pseudogene 1 LOC115294 8q11.22 similar to hypothetical protein FLJ10883 LOC389657 8 LOC389657 ST18 8q11.21 suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) LOC389658 8 similar to RPLK9433 RB1CC1 8p22-q11.23 RB1-inducible coiled-coil 1 GPR7 10q11.2-q21.1 G protein-coupled receptor 7 LOC392219 8 similar to ring finger protein 2 OPRK1 8q11.2 opioid receptor, kappa 1 LOC392220 8 similar to L21 ribosomal protein MAPK6PS1 8q11.23 similar to L21 ribosomal protein ATP6V1H 8p22-q22.3 ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H RGS20 8q11.22-q11.23 regulator of G-protein signalling 20 TCEA1 3p22-p21.3 transcription elongation factor A (SII), 1 LYPLA1 6pter-p25.1 lysophospholipase I TDGF5 8q11.23 teratocarcinoma-derived growth factor 5, pseudogene MRPL15 8q11.2-q13 mitochondrial ribosomal protein L15 LOC392221 8 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein SOX17 8q11,22 SRY (sex determining region y)-box 17 LOC389659 8 hypothetical gene supported by BC028018 LOC392222 8 similar to RIKEN cDNA 0610038D11 LOC157708 8q11.23 similar to SPC18 protein RP1 8q11.21-q11.23 retinitis pigmentosa 1 (autosomal dominant) LOC392223 8 similar to ribosomal protein L7-like 1 LOC389660 8 similar to polycystin 1-like 3 LOC392224 8 similar to hypothetical protein 4932417K07 KIAA1889 8q11.23 KIAA1889 protein FLJ32370 8q11.23 hypothetical protein FLJ32370 NCOA6IP 8p11 nuclear receptor coactivator 6 interacting protein LYN 8q13 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog PSMC6P 8q11.23 proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene RPS20 8 ribosomal protein S20 MOS 8q11 v-mos Moloney murine sarcoma viral oncogene homolog PLAG1 8q12 pleiomorphic adenoma gene 1 MGC2217
    RNA
    TRANSCRIPTS type messenger
    text two potential transcriptional termination signal sequences downstream from the consensus polyadenylation signal are proposed (PARK)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 2784 34 301 - 1993 7626141
  • isoform 1
  • 10 splicing 2721 31.5 280 - 1993 7626141
  • isoform 2
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
     stomach   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic Hydrophilic
    STRUCTURE
    motifs/domains
  • N-terminal domain is not needed for transcriptional activity, a LW motif, predominantly nuclear localized
  • C2C2 zinc finger domain
  • multiple consensus phosphorylation sites
  • HOMOLOGY
    interspecies homolog to murine Tcea1
    homolog to C.elegans T24M10.1
    Homologene
    FAMILY transcription factor S.II family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • stimulating the RNA polymerase II elongation complex
  • role in transcription recovery and re-establishment of the balance between hypo- and hyper-phosphorylated RNAPolII after DNA damage repair
  • may be required to couple transcription to repair by catalyzing the reverse translocation of the arrested polymerase, allowing access of repair proteins to the site of DNA damage
  • is not limiting for the repair of transcription-blocking DNA lesions and thus the present work does not support a role for TCEA1 in transcription-coupled nucleotide excision repair
  • having a positive role in transcription of pro-oncogenic genes, its expression is elevated in various tumors
  • can influence the proliferative potential, survival and differentiation of myeloid cells
  • CELLULAR PROCESS nucleotide, transcription, elongation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • POLR3K, RNA polymerase II in absence of transcription
  • cooperating with a transcriptional activator (EAF2)
  • bind a carrier protein(s) that accomplishes nuclear import
  • key target of RNF20 tumor suppressor activity
  • dual mode of transcriptional repression by RECQL5 that includes structural mimicry of the POLR2A-TCEA1 interaction
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS