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FLASH GENE

Symbol

TBXA2R

contributors: mct/npt - updated : 12-02-2010

HGNC name	thromboxane A2 receptor
HGNC id	11608

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	TBXA2R bleeding diathesis
Location	19p13.3      Physical location : 3.594.503 - 3.606.831
Synonym name	prostanoid TP receptor
Synonym symbol(s)	TA2R, TXA2-R

DNA

TYPE	functioning gene
STRUCTURE	12.16 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
motif	repetitive sequence
text structure	two promoters Prm1 and Prm3 located 5' of E1 and E1b
	a functional AP-1 and octamer motif are required for basal promoter activity

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001060 3 splicing 2619 NP_001051 - 343 placenta 2002 12180983 also called TBXA2R Isof 1 or Alpha (TXRA) E1 and E1b sequences NM_001060 4 splicing 1959 NP_963998 - 407 endothelium 2002 12180983 also called TBXA2R Isof 2 or beta differing only in their C-terminal tails

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Urinary kidney

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Endocrine islet cell (alpha,beta...)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven transmembrane segments (7TM) receptor
	conserved NPXXY motif in transmembrane domain 7 that is a key structural element in family A G protein-coupled receptors
	ligand binding site within the C-terminal portion of the third extracellular domain

HOMOLOGY

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	receptor for thromboxane a2 (TXA2), a potent stimulator of platelet aggregation
	play important roles in the pathogenesis of aspirin-intolerant asthma
	has a significant prognostic value in clinical breast cancer

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interaction between TBXA2R, receptor involved in oxidative stress and PRDX4, an anti-oxidative enzyme
	interacts with the GNAQ, thereby activating phospholipase C and increasing the intracellular calcium level

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

TBXA2R

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in aggressive breast tumours and linked with poor prognosis

Susceptibility

asthma in japanese population

Variant & Polymorphism SNP	T924C polymorphism potentially associated with bronchial asthma in a Japenese population

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS