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FLASH GENE
Symbol TBPL2 contributors: mct - updated : 17-06-2009
HGNC name TATA box binding protein like 2
HGNC id 19841
Location 14q22.2      Physical location : 55.880.931 - 55.907.263
Synonym name
  • TBP-related factor 3
  • TBP-like protein 2
  • Synonym symbol(s) TBP2, TRF3
    DNA
    TYPE functioning gene
    STRUCTURE 26.34 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1304 41 375 - 2007 17570761
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • non-conserved N terminal domain, intrinsically unstructured and, even though variable among vertebrates, comprising a highly conserved motif not found in any other known protein
  • DNA binding domain (DBD) was well conserved during evolution
  • a conserved C terminal domain
  • HOMOLOGY
    Homologene
    FAMILY
  • TATA box binding protein (TBP) family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II
  • bimodular protein that could perform important functions in gametogenesis
  • has a general master role within the transcription apparatus
  • TBPL2 and TAF3 are likely also required for hematopoiesis initiation
  • essential for the differentiation of female germ cells
  • plays a critical and specialized role in mammalian female germ cell development, and plays an essential and direct role in mediating oocyte-specific transcription during folliculogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • group of the intrinsically unstructured proteins
  • forms a complex with TLR9 and promotes association of IRF7 and AP3B1
  • INTERACTION
    DNA DNA binding
    RNA
    small molecule
    protein
  • should bind to the TATA box and interact with the proteins binding to TBP carboxy-terminal domain, such as the TBP associated factors (TAFs)
  • MYOD1 targets TAF3/TBPL2 to activate myogenin transcription
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS