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FLASH GENE
Symbol TBKBP1 contributors: mct/npt - updated : 10-10-2009
HGNC name TBK1 binding protein 1
HGNC id 30140
Location 17q21.32      Physical location : 45.772.629 - 45.789.427
Synonym name
  • ProSAPiP2 protein
  • TBKBP1 protein
  • similar to NAP1 TBK1 adaptor
    • Synonym symbol(s) ProSAPiP2, KIAA0775, SINTBAD
    DNA
    TYPE functioning gene
    STRUCTURE 16.80 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 4150 - 615 - Ryzhakov (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Nervousbrain   predominantly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal moderately
    cell lineage
    cell lines
  • three pooled meningiomas
  • duodenal adenocarcinoma
    • fluid/secretion cord blood
    at STAGE
    physiological period embryo, pregnancy
    Text cord blood
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • potassium channel HCN family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text located in dendrites and spines (Liebau 2009)
    basic FUNCTION
  • part of the interaction network in the TNF/NFKB pathway
  • DNA-dependent RNA polymerase catalyzing
  • the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • upon infection with Sendai virus, is essential for the efficient induction of IRF-dependent transcriptionb (Ryzhakov 2007)
  • essential for the efficient induction of IRF-dependent transcription, as are two further TBK1 adaptors, TANK and AZI2 (Ryzhakov 2007)
  • TANK with AZI2 or TBKBP1 assemble TBK1 and IKKE complexes (Chau 2008)
  • could be involved in the linkage between molecules of the postsynaptic density and the cytoskeleton (Liebau 2009)
  • may play a role as a linker molecule (interaction partner of TBK1 in the signaling pathway of NFKB and a signaling cascade that is known to be important for neuronal differentiation and synaptic plasticity (Liebau 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds TBK1 and IKBKE but not related kinases (Rhyzhakov 2007)
  • binds to the PDZ domain of ProSAP2/SHANK3 (Liebau 2009)
  • interacts with the actin cytoskeleton and could be a modulator of postsynaptic morphology in response to different signaling cascades including the NFKB pathway (Liebau 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS