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FLASH GENE
Symbol TBCEL contributors: - updated : 18-10-2007
HGNC name tubulin folding cofactor E-like
HGNC id 28115
Location 11q23.3      Physical location : 120.894.802 - 120.960.352
Synonym name
  • E-like
  • leucine rich repeat containing 35
  • Synonym symbol(s) El, LRRC35, FLJ14177, MGC10233
    DNA
    TYPE functioning gene
    STRUCTURE 63.00 kb     8 Exon(s)
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 1781 48 424 - Bartolini, 2005
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveesophagus   moderately
    Endocrineparathyroid   predominantly
     thyroid   moderately
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six LRR (leucine-rich) repeats
  • an ubiquitin-like domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to chimpanzee LRRC35 (99.1 pc)
    homolog to rattus Lrrc35 (96.2 pc)
    homolog to murine Tbcel (96.7 pc)
    intraspecies homolog to TBCE (23 pc amino acid identity)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • acting as a regulator of tubulin stability
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    text
  • protein modification process
  • PATHWAY
    metabolism
    signaling
    a component
  • phosphoserine
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS