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FLASH GENE
Symbol TBC1D8 contributors: - updated : 07-09-2004
HGNC name TBC1 domain family, member 8 (with GRAM domain)
HGNC id 17791
Location 2q12.1      Physical location : 101.623.690 - 101.767.846
Synonym name BUB2-like protein 1
vascular Rab-GAP/TBC-containing
Synonym symbol(s) HBLP1, BUB2-like protein 1, VRP, AD3
DNA
TYPE functioning gene
STRUCTURE 52.00 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LAF4 2q11.2-q12 lymphoid nuclear protein related to AF4 LOC389009 2 LOC389009 FLJ45273 2q12.1 FLJ45273 protein HCP7 2q11.2 cytochrome c, somatic pseudogene CHST10 2p11.2 carbohydrate sulfotransferase 10 LOC129522 2q12.1 similar to RalA binding protein 1 (RalBP1) (Ral interacting protein 1) (76-kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) LOC129521 2q12.1 similar to hypothetical protein VIAF1 2q12.1 IAP-associated factor VIAF1 LOC150580 2q12.1 similar to hypothetical protein FLJ39426 LOC389010 2 LOC389010 NPAS2 2p11.2-q12 neuronal PAS domain protein 2 RPL31 2q12.1 ribosomal protein L31 TBC1D8 2q12.1 TBC1 domain family, member 8 (with GRAM domain) C40 2q12.1 hypothetical protein C40 LOC389011 2 LOC389011 LOC391410 2 similar to peptidyl-Pro cis trans isomerase RNF149 2q12.1 ring finger protein 149 CREG2 2q11.2 ring finger protein 149 LOC389012 2 similar to hypothetical protein MGC33442 LOC389013 2 LOC389013 LOC389014 2 LOC389014 LOC391411 2 similar to ribosomal protein S6 LOC391412 2 similar to Lysosomal Pro-X carboxypeptidase precursor (Prolylcarboxypeptidase) (PRCP) (Proline carboxypeptidase) (Angiotensinase C) (Lysosomal carboxypeptidase C) MAP4K4 2q11.2 mitogen-activated protein kinase kinase kinase kinase 4 FLJ20373 2q12.1 hypothetical protein FLJ20373 IL1R2 2q12 interleukin 1 receptor, type II IL1R1 2q12 interleukin 1 receptor, type I IL1RL2 2q12 interleukin 1 receptor-like 2 IL1RL1 2q12 interleukin 1 receptor-like 1 IL18R1 2q12 interleukin 18 receptor 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GRAM domain
  • a TBC domain
  • HOMOLOGY
    interspecies homolog to murine Tbc1d8
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • GTPase activator activity
  • playing a role in positive regulation of cell proliferation
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS