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FLASH GENE
Symbol TBC1D5 contributors: mct - updated : 05-01-2011
HGNC name TBC1 domain family, member 5
HGNC id 19166
Location 3p24.3      Physical location : 17.198.654 - 17.784.240
Synonym symbol(s) KIAA0210, TBC5
DNA
TYPE functioning gene
STRUCTURE 585.59 kb     24 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
NR2C2 3p25 nuclear receptor subfamily 2, group C, member 2 MRPS25 3p25 mitochondrial ribosomal protein S25 ZFYVE20 3p25.1 zinc finger, FYVE domain containing 20 LOC344875 3p25.1 similar to RIKEN cDNA E330026B02 CAPN7 3p24 calpain 7 SH3BP5 1q43 SH3-domain binding protein 5 (BTK-associated) LOC389097 3 similar to Nonhistone chromosomal protein HMG-17 (High-mobility group nucleosome binding domain 2) MGC24132 3p25.1 hypothetical protein MGC24132 EAF1 3q25.1 ELL associated factor 1 COLQ 3p24.2 collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase HPCL2 3p25.1 2-hydroxyphytanoyl-CoA lyase BTD 3p25 biotinidase KIAA0379 3p25.2-p24.2 biotinidase LOC131961 3p25.1 similar to inosine monophosphate dehydrogenase 1 isoform a; sWSS2608 GALNT7 4q31.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) MGC15763 3p25-p24 hypothetical protein BC008322 RAFTLIN 3p25.1 raft-linking protein DAZL 3p24 deleted in azoospermia-like PLCL2 3p24.3 phospholipase C-like 2 TBC1D5 3p24.3 TBC1 domain family, member 5 LOC151842 3p24.3 inorganic pyrophosphatase pseudogene LOC391516 3 similar to IAP-associated factor VIAF1; phosducin-like 2 SATB1 3p24.3-p23 special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's) LOC389098 3 LOC389098 LOC131185 3p24.3 similar to UV excision repair protein RAD23 homolog B (HHR23B) (XP-C repair complementing complex 58 kDa protein) (P58) KCNH8 3p24.3 potassium voltage-gated channel, subfamily H (eag-related), member 8
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 6631 - 795 - 1996 9039502
isoform b
24 - 6534 - 817 - 1996 9039502
isoform a
22 - 7869 - 795 - 1996 9039502
isoform b
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart   highly
Nervousbrain    
 gangliasensory gangliadorsal root  
 spinal cord    
Reproductivefemale systemovary   
 female systemuterus   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • TBC domain
  • HOMOLOGY
    Homologene
    FAMILY
  • Rab GAP family of proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • putative GTPase activator protein of RAB-like small GTPase
  • retromer-interacting protein, negatively regulating VPS35/VPS29/VPS26A recruitment and causing RAB7A to dissociate from the membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS