Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TBC1D21 contributors: mct - updated : 04-12-2018
HGNC name TBC1 domain family member 21
HGNC id 28536
Location 15q24.1      Physical location : 74.165.967 - 74.181.553
Synonym name
  • Male Germ Cells Rab GTPase-Activating Proteins
  • Synonym symbol(s) MGCRABGAP
    DNA
    TYPE functioning gene
    STRUCTURE 38.62 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1259 - 336 - 2011 21128978
    10 - 1151 - 300 - 2011 21128978
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved RABGAP catalytic domain, TBC (Tre2/Bub2/Cdc16)
  • HOMOLOGY
    Homologene
    FAMILY RABGAP family
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • is likely involved in acrosome/acroplaxome formation and cytoskeletal reorganization via RAB activity during mammalian spermiogenesis
  • is a male germ cell-specific protein expressed in elongating and elongated spermatids during mammalian spermiogenesis
  • is a protein specifically expressed in the testes that exhibits specific localizations of elongating and elongated spermatids during mammalian spermiogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TBC1D21 is involved in mammalian spermiogenesis by modulating RAB10
  • TBC1D21 may likely interact with and potentially regulate RABGEF1 during spermatogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS