basic FUNCTION
| is required for direct interaction with optineurin |
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through its catalytic activity, TBC1D17 inhibits recruitment of RAB8A to the tubules and reduces colocalisation of transferrin receptor and RAB8A |
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TBC1D15 and TBC1D17 mediate proper autophagic encapsulation of mitochondria by regulating RAB7A activity at the interface between mitochondria and isolation membranes |
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localized to autophagosomes and inhibited autophagy flux dependent on its catalytic activity |
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GTPase-activating protein for RAB GTPases, playing a crucial role in mutant OPTN E50K-induced impaired autophagy and cell death |