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FLASH GENE
Symbol TBC1D15 contributors: mct - updated : 25-08-2011
HGNC name TBC1 domain family, member 15
HGNC id 25694
Location 12q21.1      Physical location : 72.233.486 - 72.320.627
Synonym name
  • GAP for RAB7
  • GTPase-activating protein RAB7
  • Synonym symbol(s) DKFZp686M1379, DKFZp761D0223, FLJ12085, FLJ33191, RAB7-GAP
    EC.number 1.15.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 87.14 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 5852 - 682 - 2010 2036373
    14 - 5811 - 691 - 2010 2036373
    13 - 5760 - 674 - 2010 2036373
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY Ypt/Rab-GAP, TBC domain family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text localized predominantly to the cytosol
    basic FUNCTION
  • potentially involved in RAB7A-mediated late endosomal trafficking
  • TBC1D15 and and VPS39 regulate lysosomal morphology and play a role in maintaining growth factor dependence
  • mitochondrial Rab GTPase-activating protein (Rab-GAP), governs autophagosome biogenesis and morphology downstream of Parkin activation
  • TBC1D15 and TBC1D17 mediate proper autophagic encapsulation of mitochondria by regulating RAB7A activity at the interface between mitochondria and isolation membranes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • TBC1D17, also participates in mitophagy and forms homodimers and heterodimers with TBC1D15
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS