Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TBC1D10C contributors: mct - updated : 16-06-2015
HGNC name TBC1 domain family, member 10C
HGNC id 24702
Location 11q13.1      Physical location : 67.171.411 - 67.177.559
Synonym name
  • carabin
  • Synonym symbol(s) EPI64C, CARABIN
    DNA
    TYPE functioning gene
    STRUCTURE 6.40 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1752 - 446 - 2008 18450757
    9 - 1541 - 310 - 2008 18450757
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Lymphoid/Immunelymph node   moderately
     spleen   moderately
     thymus   moderately
     tonsils   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiacmyocardium  Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion highly in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • calcineurin-interacting site
  • Ras/Rab GTPase-activating protein domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as an endogenous inhibitor of calcineurin
  • also inhibiting the Ras signalling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity
  • TBC1D10C and RAB35 regulate a recycling pathway in T cells and contribute to immunological synapse (IS) formation, most likely by participating in TCR transport to the IS
  • TBC1D10A, TBC1D10C regulate exosome secretion in a catalytic activity-dependent manner
  • functions as an endogenous inhibitor of calcineurin and Ras/extracellular signal-regulated kinase prohypertrophic signaling
  • negative regulator of key prohypertrophic signaling molecules, calcineurin, RAS, and Ca(2+)/calmodulin-dependent protein kinase II, implicated in the development of cardiac hypertrophy and failure
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
  • constituting part of a negative regulatory loop for the intracellular TCR signalling pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RAB35 (RAB35 regulate a recycling pathway in T cells and contribute to immunological synapse formation, most likely by participating in T-cell receptor transport to the immunological synapse)
  • haematopoietically enriched GTPase-activating protein (GAP) for RAB35, that has been shown to exhibit RasGAP activity
  • cell & other
    REGULATION
    Other expression is upregulated on TCR signalling in a manner that is sensitive to inhibitors of calcineurin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in cardiac hypertrophy and human heart failure
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Carabin(-/-) mice developed exaggerated cardiac hypertrophy and displayed a strong decrease in fractional shortening