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FLASH GENE
Symbol TBC1D10A contributors: mct/npt - updated : 16-06-2016
HGNC name TBC1 domain family, member 10A
HGNC id 23609
Location 22q12.2      Physical location : 30.687.979 - 30.722.894
Synonym name
  • EBP50-PDZ interactor of 64 kD
  • TBC1 domain family, member 10
  • RAB27A-GAP-alpha
  • Synonym symbol(s) EPI64, TBC1D10, dJ130H16.1, dJ130H16.2, AC004997.C22.2
    DNA
    TYPE functioning gene
    STRUCTURE 34.98 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2017 57.1 508 - 2008 1845075
    9 - 2038 - 515 - 2008 1845075
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineplacenta   highly
    Lymphoid/Immunespleen   highly
    Nervousbrain    
    Reproductivefemale systemovary   
     female systembreastmammary gland highly
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal Tre-2/Bub2/Cdc16 (TBC) domain that stabilizes active ARF6, has RabGAP activity, and is required for the accumulation of vacuoles
  • a PDZ domain
  • HOMOLOGY
    interspecies homolog to murine Tbc1d10
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • PDZ-domain binding activity
  • TBC domain-containing protein that regulates microvillar subdomains and structure
  • GTPase-activating protein specific for RAB27A
  • TBC1D10A, TBC1D10C regulate exosome secretion in a catalytic activity-dependent manner
  • apical microvillar protein, regulating ARF6-dependent membrane trafficking
  • regulates membrane trafficking both by stabilizing ARF6-GTP and by inhibiting the recycling of membrane through the tubular endosome by decreasing RAB8A-GTP levels
  • TBC1D10A, CYTH2 regulate endocytosis at distinct stages
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds the PDZ domains of SLC9A3R1, which binds ezrin, a major actin-binding protein of microvilli
  • TBC1D10A interacts with SYTL1 to coordinate RAB8A and ARF6 membrane trafficking
  • peripheral CYTH2 recruits TBC1D10A to the same area and the interaction requires glucose-induced endocytosis in pancreatic beta-cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS