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FLASH GENE
Symbol TAX1BP3 contributors: shn/pgu - updated : 27-09-2012
HGNC name Tax1 (human T-cell leukemia virus type I) binding protein 3
HGNC id 30684
Location 17p13      Physical location : 3.566.189 - 3.571.973
Synonym name
  • Tax interaction protein 1
  • tax-interacting protein 1
  • tax1-binding protein 3
  • glutaminase-interacting protein 3
  • glutaminase interacting protein
  • Synonym symbol(s) TIP1, TIP-1, GIP
    DNA
    TYPE functioning gene
    STRUCTURE 5.00 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - CTNS CTNS - TIP1 - P2RX5 - ITGAE - cen
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Digestiveintestinesmall intestine  highly Homo sapiens
    Nervousbrain   highly Homo sapiens
    Respiratorylung   highly Homo sapiens
    Urinarykidney   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal moderately Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single PDZ domain
  • S2P metal dependent membrane associated protease domain
  • HOMOLOGY
    interspecies ortholog to Tax1bp3, Mus musculus
    ortholog to tax1bp3, Danio rerio
    ortholog to TAX1BP3, Pan troglodytes
    Homologene
    FAMILY
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in Rho signaling to the serum response element
  • functioning as a negative regulator of PDZ-based scaffolding
  • may play a similar role in regulating the expression of other membrane proteins containing a type I PDZ ligand
  • may represent a novel regulatory element in the Wnt/beta-catenin signaling pathway
  • TAX1BP3 may act as an important regulator for the endocytic pathway of KCNJ4
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text important roles in cellular signaling, protein scaffolding and modulation of tumor growth (
    PATHWAY
    metabolism
    signaling
    a component Rho-rhotekin-TIP1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Rho effector rhotekin (
  • Glutaminase L (
  • beta-catenin (
  • Kir 2.3 (
  • brain-specific angiogenesis inhibitor 2, BAI2
  • FAS, HTLV-1 Tax, HPV16 E6,
  • atypical PDZ-domain-containing protein, binding to KCNJ4 with a high affinity, causing the intracellular accumulation of KCNJ4 in cultured epithelial cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS