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FLASH GENE
Symbol TAX1BP1 contributors: mct/npt - updated : 25-09-2009
HGNC name Tax1 (human T-cell leukemia virus type I) binding protein 1
HGNC id 11575
Location 7p15.2      Physical location : 27.779.737 - 27.869.384
Synonym name TRAF6-binding protein
Synonym symbol(s) T6BP, TXBP151, CALCOCO3
DNA
TYPE functioning gene
STRUCTURE 89.65 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
EVX1 7p15-p14 eve, even-skipped homeo box homolog 1 (Drosophila) LOC392008 7 similar to 60S ribosomal protein L35 NSG-X 7q31 brain and nasopharyngeal carcinoma susceptibility protein LRRC4 7q31 leucine rich repeat containing 4 TAX1BP1 7p15 Tax1 (human T-cell leukemia virus type I) binding protein 1 LOC392009 7 similar to protease (prosome, macropain) 26S subunit, ATPase 1 JAZF1 7p15 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC392010 7 similar to hypothetical protein MGC2574 LOC392648 7 LOC392648 LEP 7q31.3 leptin (obesity homolog, mouse) HIBADH 7p15.2 3-hydroxyisobutyrate dehydrogenase MGC27345 7q32.2 hypothetical protein MGC27345 FLJ10377 7q32.2 hypothetical protein FLJ10377 LOC392783 7 hypothetical gene supported by BC063892 IMPDH1 7q31.3-q32 IMP (inosine monophosphate) dehydrogenase 1 HIG2 7q32.2 hypoxia-inducible protein 2 TAX1BP1 7p15 Tax1 (human T-cell leukemia virus type I) binding protein 1 METTL2 17q24.1 methyltransferase like 2 LOC392784 7 hypothetical gene supported by BC044925; NM_006852 JAZF1 7p15 hypothetical gene supported by BC044925; NM_006852 LOC389474 7 LOC389474 LOC392785 7 hypothetical gene supported by AL137733 LOC392786 7 hypothetical gene supported by BC062355 LOC392985 7 similar to capicua homolog LOC392881 7 similar to peptidylprolyl isomerase A LOC346653 7q32.2 hypothetical protein LOC346653 NYD-SP18 7q32.2-q32.3 testes development-related NYD-SP18 CALU 7q32 calumenin OPN1SW 7q31.3-q32 opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) DKFZP434G156 7q33 hypothetical protein DKFZp434G156 CREB5 7p15 cAMP responsive element binding protein 5 FLNC 7q32 filamin C, gamma (actin binding protein 280) ATP6V1F 7q32 ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F LOC392787 7 similar to Filamin C (Gamma-filamin) (Filamin 2) (Protein FLNc) (Actin-binding like protein) (ABP-L) (ABP-280-like protein) IRF5 7q32 interferon regulatory factor 5
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 3340 - 747 - Morriswood (2007)
17 - 3466 - 789 - Morriswood (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Digestiveesophagus   moderately
 pharynx   moderately
Endocrineadrenal gland   moderately
 neuroendocrinepituitary  highly
Skin/Tegumentskin   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately
Connectiveadipose  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text moderately in umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal novel membrane binding domain termed SKIP carboxyl homology (SKICH)
  • three central coiled-coil domains
  • two C-terminal zinc-finger domains
  • mono polymer homomer , oligo
    HOMOLOGY
    interspecies homolog to rattus Tax1bp1 (87 pc)
    homolog to murine Tax1bp1 (87.2 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nuclear envelope
    text TAX1BP1 and CNTN2 colocalize into intranuclear speckles that partially overlap with but are not identical to the PML oncogenic domains
  • with CALCOCO2 and myosin VI are present at the trans side of the Golgi complex, and on vesicles in the perinuclear region(Morriswood 2007)
  • basic FUNCTION
  • inhibiting TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity
  • may also play a role in the pro-inflammatory cytokine IL-1 signaling cascade
  • playing a pivotal role for the termination of NFKB and JNK signaling by functioning as an essential regulator of TNFAIP3
  • nuclear receptor coactivator that forms a complex with the glucocorticoid receptor
  • inhibit NF-kappaB activation, and is implicated in the regulation of TRAF6-mediated cytokine signalling (Morriswood 2007)
  • together with TAX1BP1 and ITCH, is an essential component of an TNFAIP3 ubiquitin-editing protein complex that ensures transient activation of inflammatory signalling pathways (Shembade 2009)
  • functions as an adaptor molecule for TNFAIP3 and together they target TBK1 and IKKBE to inhibit IFNB production
  • pivotal for the termination of NF-kappaB and JNK signaling by functioning as an essential regulator of TNFAIP3 (Shembade 2009)
  • TNIP1 cooperates with TAX1BP1 and TNFAIP3 to restrict antiviral signaling
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with TRAF6 in a IL-1-dependent manner (interaction between the N-terminal zinc and ring finger domains of TRAF6 and either the N-terminal first coiled-coil region or the 2 coiled-coil regions of the C-terminus of TAX1BP1)
  • interacting with TNFAIP3 (functioning as a negative regulator of ubiquitination of key signaling molecules that are also targeted by TNFAIP3)
  • interacting with STARD13
  • interacting with the HTLV-1 protein Tax-1
  • interactig with CNTN2
  • myosin VI binding partner (myosin VI-TAX1BP1 interactions may link membrane trafficking pathways with cell adhesion and cytokine-dependent cell signalling)(Morriswood 2007)
  • interacts cooperatively with OPTN (OPTN and TAX1BP1 cooperate to modulate Tax1 ubiquitination and NF-kappaB activation)(Journo 2009)
  • TNIP1 requires its ubiquitin binding domain and cooperates with TAX1BP1 and TNFAIP3 to restrict antiviral signaling
  • cell & other
    REGULATION
    Other degraded by caspase-3-like family proteins upon TNF-induced apoptosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • TAX1BP1 knocked out mice (Iha, 2008)