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FLASH GENE
Symbol TAS2R8 contributors: SGE/npt - updated : 11-06-2010
HGNC name taste receptor, type 2, member 8
HGNC id 14915
Location 12p13.2      Physical location : 10.958.650 - 10.959.579
Synonym name
  • candidate taste receptor T2R8
  • taste receptor, family B, member 5
  • Synonym symbol(s) T2R8, TRB5
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text cluster interspersed with the proline rich protein cluster
    STRUCTURE 0.93 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KLRD1 12p13.2-p13.1 killer cell lectin-like receptor subfamily D, member 1 KLRK1 12p13.2-p13.1 killer cell lectin-like receptor subfamily K, member 1 KLRC4 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 4 KLRC3 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 3 KLRC2 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 2 KLRC1 12p13.2-p13.1 killer cell lectin-like receptor subfamily C, member 1 LOC255308 12p13.31 similar to eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa; eukaryotic translation initiation factor 2G; eukaryotic translation initiation factor 2, subunit 3 (gamma, 52kD) KLRA1 12p13.2-p13.1 killer cell lectin-like receptor subfamily A, member 1 FLJ10292 12p13.31 hypothetical protein FLJ10292 DKFZp761P1010 12p13.31 hypothetical protein DKFZp761P1010 CSDA 12p13.1 cold shock domain protein A LOC387838 12 LOC387838 TAS2R7 12p13 taste receptor, type 2, member 7 TAS2R8 12p13 taste receptor, type 2, member 8 TAS2R9 12p13 taste receptor, type 2, member 9 TAS2R10 12p13 taste receptor, type 2, member 10 PROL4 12p13 proline rich 4 (lacrimal) PRH1 12p13.2 proline-rich protein HaeIII subfamily 1 PRH2 12p13.2 proline-rich protein HaeIII subfamily 2 TAS2R13 12p13 taste receptor, type 2, member 13 TAS2R14 12p13 taste receptor, type 2, member 14 PS8 12p13.31 bitter taste receptor pseudogene 8 TAS2R50 12p13.31 taste receptor, type 2, member 50 TAS2R49 12p13.31 taste receptor, type 2, member 49 TAS2R48 12p13.31 taste receptor, type 2, member 48 TAS2R44 12p13.31 taste receptor, type 2, member 44 TAS2R63P 12p13.31 taste receptor, type 2, member 63 pseudogene TAS2R46 12p13.31 taste receptor, type 2, member 46 TAS2R64P 12p13.31 taste receptor, type 2, member 64 pseudogene TAS2R43 12p13.31 taste receptor, type 2, member 43 hT2R55 12p13 candidate taste receptor hT2R55
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 930 - 309 - Matsunami (2000)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    digestivemouthpalate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Epithelialsensorygustatory  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Gustatoryclear receptor cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • an extracellular lignand binding domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to a bitter cluster on murine chromosome 6
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • taste receptor family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • taste receptor cells of the tongue and palate epithelia
  • receptor that may play a role in the perception of bitterness and is gustducin-linked
  • may play a role in sensing the chemical composition of the gastro intestinal content
  • may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/taste
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS