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FLASH GENE
Symbol TAS2R38 contributors: mct - updated : 10-10-2011
HGNC name taste receptor, type 2, member 38
HGNC id 9584
Location 7q34      Physical location : 141.672.430 - 141.673.573
Synonym name
  • phenylthiocarbamide tasting
  • PTC bitter taste receptor
  • Synonym symbol(s) PTC, T2R61
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status provisional
    Map cen - D7S684 - D7S2468 - D7S2505 - [D7S1518 - LCHN - D7S1824 - D7S2202 ]- CLEC5A - D7S2473 - MGAM MGAM - EPHB6 - KEL KEL - D7S2513 - CASP2 ,EPHA1 - D7S661 -D7S3068 - qter
    Authors Kim (03)
    Text [PTC ]
    Physical map
    FLJ10842 7q34 hypothetical protein FLJ10842 FLJ40852 7q34 hypothetical protein FLJ40852 SSBP1 7q34 single-stranded DNA binding protein TAS2R3 7q31.3-q32 taste receptor, type 2, member 3 TAS2R4 7q31.3-q32 taste receptor, type 2, member 4 TAS2R5 7q31.3-q32 taste receptor, type 2, member 5 LOC136242 7q34 similar to RIKEN cDNA 1700016G05 LOC392106 7 similar to olfactory receptor MOR120-3 OR9A1P 7q32.3 olfactory receptor, family 9, subfamily A, member 1, pseudogene LOC130075 7q34 similar to Olfactory receptor 9A4 CLECSF5 7q33 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5 TAS2R38 7q34 taste receptor, type 2, member 38 MGAM 7q31.3 maltase-glucoamylase (alpha-glucosidase) LOC93432 7q34 hypothetical protein LOC93432 LOC136542 7q34 dopamine-beta-hydroxylase-like pseudogene TRY1 7q34 trypsinogen-like pseudogene TRY2 7q34 trypsinogen-like pseudogene TRY3 7q34 trypsinogen-like pseudogene
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    digestivemouthpalate   
    Nervousbrainforebraincerebral cortex   Homo sapiens
     brainhindbraincerebellum   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell Homo sapiens
    Gustatoryclear receptor cell
    Respiratoryepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments(7TM) receptor
  • an extracellular ligand binding domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Tas2r138
    homolog to rattus T2R38
    Homologene
    FAMILY G-protein coupled receptor T2R family
    CATEGORY signaling neurotransmitter , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • directly influencing on phenylthiocarbamide taste sensitivity and involved in bitter perception
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text G-protein coupled receptor protein signaling pathway
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/taste
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    good taster
    constitutional        
    non-taster
    Susceptibility
    Variant & Polymorphism other
  • haplotype Pro-Ala-Val associated with phenotype good taster
  • haplotype Arg-Val-Isoleu associated with phenotype non-taster
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS