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FLASH GENE
Symbol TAS2R16 contributors: mct - updated : 08-06-2011
HGNC name taste receptor, type 2, member 16
HGNC id 14921
Location 7q31.32      Physical location : 122.634.758 - 122.635.754
Synonym name candidate taste receptor T2R16
Synonym symbol(s) T2R16
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 0.99 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - TAS2R16 - TAS2R3 - TAS2R4 - TAS2R5 - qter
Authors Adler (00)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 996 - 291 - 2006 12379855
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
digestivemouthpalate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
Epithelialsensorygustatory  
cells
SystemCellPubmedSpeciesStageRna symbol
Gustatoryclear receptor cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • an extracellular lignand binding domain
  • HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • taste receptor family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in bitter perception
  • utilized to recognize and perceive the structure and bitterness of peptides
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/taste
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • gentiobiose and salicin share a common binding site of TAS2R16
  • molecular interaction between hTAS2R16 and beta-D-glucopyranoside (
  • cell & other
    REGULATION
    activated by by bitter beta-glucopyranoside
    bitter peptides
    gentiobiose (activated TAS2R16, a bitter taste receptor, but not TAS1R2/TAS1R3, a sweet taste receptor
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to alcohol dependence
    Variant & Polymorphism SNP SNP K172N, shows significant association with alcohol dependence, partcularly in the African American population
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS