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FLASH GENE
Symbol TAS1R1 contributors: mct/npt - updated : 25-04-2017
HGNC name taste receptor, type 1, member 1
HGNC id 14448
Location 1p36.31      Physical location : 6.615.337 - 6.639.816
Synonym name
  • G protein-coupled receptor 70
  • sweet taste receptor T1r
  • Synonym symbol(s) TR1, T1R1, GPR70, gm148
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 24.38 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located with TAS1R2 and TAS1R3 within a small region of chromosome 1p36
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 splicing 2373 52.4 480 - Makalowska, Chen (2009)
  • lacking an alternate segment, causing a frameshift compared to variant 2
  • 6 splicing 2707 92.9 841 - Makalowska, Chen (2009)
    5 splicing 1945 65 587 - Makalowska, Chen (2009)
    lacking an alternate in-frame exon compared to variant 2
    6 splicing 1302 35.4 324 - Makalowska, Chen (2009)
  • lacking an alternate segment and utilizing an alternate splice site, one of which causes a frameshift compared to variant 2
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Digestivemouthtongue   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensorygustatory  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Gustatoryclear receptor cell
    Reproductivespermatozoa Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal extracellular binding domain
  • seven transmembrane segments (7TM)
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Tas1r1 (74.1pc)
    homolog to murine Tas1r1 (74pc)
    intraspecies paralog to TAS1R2
    paralog to TAS1R3
    Homologene
    FAMILY
  • G-protein coupled receptor 3 family
  • TAS1R subfamily
  • sweet receptor subfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • responds to the umami taste stimulus (the taste of monosodium glutamate)
  • with TAS1R3, believed to function in combination as a heteromeric glutamate taste receptor in humans (Chen 2009)
  • with TAS1R3, likely contributes to human umami taste perception (Chen 2009)
  • TAS1R1/TAS1R3 are a direct sensor of the fed state and amino acid availability
  • TAS1R1 receptor subunit acts as an umami taste receptor in combination with its partner, TAS1R3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/taste
    sweet receptor
    a component
  • forming an heterodimer with TAS1R3
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • L-amino acids "sweet" ligands
  • TAS1R1-TAS1R3 (T1R1-T1R3) can sense extracellular amino acids, activate MTOR, and inhibit autophagy
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to individual taste sensitivity to glutamate
    Variant & Polymorphism SNP , other
  • TAS1R1-TAS1R3 receptor variants found in human fungiform papillae might contribute to inter-individual differences of sensitivity to L-glutamate (Raliou 2009)
  • SNP G1114A more frequent in tasters to glutamate (Raliou 2009)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS