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FLASH GENE
Symbol TARS contributors: mct - updated : 18-05-2018
HGNC name threonyl-tRNA synthetase
HGNC id 11572
Corresponding disease
TTD7 trichothiodystrophy 7, nonphotosensitive
Location 5p13.3      Physical location : 33.440.897 - 33.468.194
Synonym name threonine tRNA ligase 1, cytoplasmic
Synonym symbol(s) ThrRS, MGC9344
EC.number 6.1.1.3
DNA
TYPE functioning gene
STRUCTURE 27.40 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
MAPPING cloned Y linked N status provisional
Map pter - D5S108 - D5S1993 - D5S1986 - D5S1996 - CDH6 - D5S477 - D5S1884 - D5S1470 - TARS - D5S651 - D5S2433 - D5S674 - TRIM28 - D5S2062 - D5S1430 - D5S1506 - D5S583 - D5S1867 - D5S1479 - D5S2077 - D5S493 - D5S663 - D5S631 - D5S426 - D5S1900 - D5S2573 - D5S1750 - D5S455 - SLC1A3 - NUP155 - MLVI2 - D5S1994 - D5S2025- D5S1859 - D5S1876 - D5S1998 - D5S395 - PRLR - LIFR - D5S1879 - D5S2592 - cen
Authors Peterson (99)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 2888 - 723 - 2013 23425968
20 - 2701 - 723 - 2013 23425968
20 - 2974 - 756 - 2013 23425968
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Reproductivefemale systemuteruscervix highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY class-II aminoacyl-tRNA synthetase family
CATEGORY enzyme , RNA associated
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • catalyzing the aminoacylation of tRNA by their cognate amino acid
  • play a role in DNA repair and cell cycle regulation (Scotto 2008)
  • class II ARS protein that catalyzes the covalent binding of threonine to a threonine-specific tRNA (tRNAThr) to form the aminoacyl Thr-tRNAThr complex
  • angiogenic, pro-migratory extracellular signaling molecule
  • is a Zn(II) containing enzyme that catalyzes the activation of threonine and its subsequent transfer to the cognate tRNA
  • TARS and TARS2 encode cytoplasmic and mitochondrial threonyl-tRNA synthetases (ThrRSs)
  • is an essential component of the translation machinery, and it belongs to the aminoacyl-tRNA synthetase (ARS) protein family
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    interacting with zinc ions
    protein
    cell & other
    REGULATION
    Other regulated by feedback mechanisms
    borrelidin competes with all three aminoacylation substrates, providing a potent and redundant mechanism to inhibit TARS during protein synthesis
    ASSOCIATED DISORDERS
    corresponding disease(s) TTD7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in epithelial ovarian cancer and correlates with markers of angiogenic progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • potential target for detecting or interdicting disease-related inflammatory or angiogenic responses
  • Marker
    Therapy target
    ANIMAL & CELL MODELS