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FLASH GENE
Symbol TARS contributors: mct - updated : 18-05-2018
HGNC name threonyl-tRNA synthetase
HGNC id 11572
Location 5p13.3      Physical location : 33.440.897 - 33.468.194
Synonym name threonine tRNA ligase 1, cytoplasmic
Synonym symbol(s) ThrRS, MGC9344
EC.number 6.1.1.3
DNA
TYPE functioning gene
STRUCTURE 27.40 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
MAPPING cloned Y linked N status provisional
Map pter - D5S108 - D5S1993 - D5S1986 - D5S1996 - CDH6 - D5S477 - D5S1884 - D5S1470 - TARS - D5S651 - D5S2433 - D5S674 - TRIM28 - D5S2062 - D5S1430 - D5S1506 - D5S583 - D5S1867 - D5S1479 - D5S2077 - D5S493 - D5S663 - D5S631 - D5S426 - D5S1900 - D5S2573 - D5S1750 - D5S455 - SLC1A3 - NUP155 - MLVI2 - D5S1994 - D5S2025- D5S1859 - D5S1876 - D5S1998 - D5S395 - PRLR - LIFR - D5S1879 - D5S2592 - cen
Authors Peterson (99)
Physical map
PGBD3P2 5p13.3 piggyBac transposable element derived 3 pseudogene 2 HPRTP2 5p14-p13.3 hypoxanthine phosphoribosyltransferase pseudogene 2 LOC391774 5 similar to hypothetical protein CDH6 5p15.32-p14.2 cadherin 6, type 2, K-cadherin (fetal kidney) RNASE3L 5p15.1 cadherin 6, type 2, K-cadherin (fetal kidney) FLJ11193 5p13.3 hypothetical protein FLJ11193 PDZK3 5p13.2 PDZ domain containing 3 GOLPH3 5p14.1 golgi phosphoprotein 3 (coat-protein) LOC202122 5p13.3 similar to ribosomal protein L27 PIP3AP 5p15.33 phosphatidylinositol-3-phosphate associated protein ZFR 5p13.2 zinc finger RNA binding protein LOC391775 5 similar to Chromosome 1 open reading frame 37 PC4 5p13.3 activated RNA polymerase II transcription cofactor 4 NPR3 5p14-p13 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) FLJ14054 5p13.3 hypothetical protein FLJ14054 LOC389278 5 similar to 40S ribosomal protein S8 TARS 5p13.3-p13.2 threonyl-tRNA synthetase LOC389279 5 similar to RPE-spondin LOC391776 5 similar to Probable mitochondrial import receptor subunit TOM40 homolog (Translocase of outer membrane 40 kDa subunit homolog) (Haymaker protein) (p38.5) ADAMTS12 5q35 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 SALPR 5p15.1-p14 G-protein coupled receptor SALPR MATP 5p13.3 membrane associated transporter protein AMACR 5p13.3-p12 alpha-methylacyl-CoA racemase C1QTNF3 5p13-p12 C1q and tumor necrosis factor related protein 3 LOC389280 5 similar to SMA3 protein LOC389281 5 similar to bA110H4.2 (similar to membrane protein) RAI14 5p13.3-p13.2 retinoic acid induced 14 FLJ25439 5p13.3 hypothetical protein FLJ25439 RAD1 5p13.3-p13.2 RAD1 homolog (S. pombe) BRIX 5p13.3 BRIX LOC134218 5p13.3 hypothetical protein LOC134218 AGXT2 5p13 alanine-glyoxylate aminotransferase 2 PRLR 5p14-p13.3 prolactin receptor LOC389282 5 similar to RIKEN cDNA C230086A09 gene FLJ23577 5p13.2 hypothetical protein FLJ23577 IL7R 5p13 interleukin 7 receptor MGC26610 5p13.2 hypothetical protein MGC26610 FLJ34658 5p13.2 hypothetical protein FLJ34658 LOC167127 5p13.2 hypothetical protein LOC167127 DKFZp434H2226 5p13.2 hypothetical protein DKFZp434H2226 SKP2 5p13 S-phase kinase-associated protein 2 (p45) FLJ30596 5p13.2 hypothetical protein FLJ30596 FLJ25422 5p13.2 hypothetical protein FLJ25422 SLC1A3 5p13 solute carrier family 1 (glial high affinity glutamate transporter), member 3 LOC345513 5p13.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) IDN3 5p13.2 IDN3 protein LOC391777 5 similar to ribosomal protein S4, X-linked FLJ13231 5p13.2 hypothetical protein FLJ13231
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 2888 - 723 - 2013 23425968
20 - 2701 - 723 - 2013 23425968
20 - 2974 - 756 - 2013 23425968
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Reproductivefemale systemuteruscervix highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY class-II aminoacyl-tRNA synthetase family
CATEGORY enzyme , RNA associated
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • catalyzing the aminoacylation of tRNA by their cognate amino acid
  • play a role in DNA repair and cell cycle regulation (Scotto 2008)
  • angiogenic, pro-migratory extracellular signaling molecule
  • is a Zn(II) containing enzyme that catalyzes the activation of threonine and its subsequent transfer to the cognate tRNA
  • TARS and TARS2 encode cytoplasmic and mitochondrial threonyl-tRNA synthetases (ThrRSs)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    interacting with zinc ions
    protein
    cell & other
    REGULATION
    Other regulated by feedback mechanisms
    borrelidin competes with all three aminoacylation substrates, providing a potent and redundant mechanism to inhibit TARS during protein synthesis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in epithelial ovarian cancer and correlates with markers of angiogenic progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • potential target for detecting or interdicting disease-related inflammatory or angiogenic responses
  • Marker
    Therapy target
    ANIMAL & CELL MODELS