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FLASH GENE
Symbol TAPBPL contributors: mct - updated : 11-04-2015
HGNC name TAP binding protein-like
HGNC id 30683
Location 12p13.31      Physical location : 6.561.176 - 6.571.486
Synonym name
  • tapasin binding protein related
  • TAP binding protein related
  • TAPASIN-R
  • Synonym symbol(s) FLJ10143, TAPBPR,
    DNA
    TYPE virus associated
    STRUCTURE 10.67 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text
  • abundance of the alternative transcripts in peripheral blood mononuclear cells and dendritic cells suggests an important role of TAPBPL isoforms (PMID: 24444341)
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1834 50 468 - 2014 24444341
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivemale systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal signal sequence
  • a region weakly similar to an Ig-like or fibronectin -like domain
  • a transmembrane region
  • a 42-residue cytoplasmic tail with no ER retention motif
  • three extracellular domains comprising a unique membrane distal domain, an IgSF (immunoglobulin superfamily) V domain and an IgC1 domain
  • a cytoplasmic region
  • HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin C-type family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • is not restricted to the ER
  • basic FUNCTION
  • is an additional component of the MHC class I antigen-presentation pathway
  • potential function of TAPBPR in the MHC class I pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TAPBPL and tapasin bind in a similar orientation to the same face of MHC class I
  • component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin
  • cell & other
    REGULATION
    induced by IFNG (IFNG inducible)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS