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FLASH GENE

Symbol

TAGLN2

contributors: mct - updated : 22-08-2013

HGNC name	transgelin 2
HGNC id	11554

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q23.2      Physical location : 159.887.902 - 159.895.284
Synonym name	SM22-alpha homolog
	epididymis tissue protein Li 7e
Synonym symbol(s)	KIAA0120, HA1756

DNA

TYPE	functioning gene
STRUCTURE	7.44 kb     5 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF
text structure	methylation of its promoter is an important event in vascular smooth muscle cell calcification (high-phosphate medium reduced DNA methyltransferase activity and prevented methylation of the promoter, which was accompanied by an increase in TAGLN2 expression and less calcification)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001277224 5 - 1608 NP_001264153 - 220 - 2001 11401431 NM_003564 5 - 1419 NP_003555 - 199 - 2001 11401431 NM_001277223 5 - 1384 NP_001264152 - 199 - 2001 11401431

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         intestine large intestine colon       liver           salivary gland       moderately Lymphoid/Immune spleen           thymus           tonsils       highly Reproductive female system uterus cervix   moderately   female system ovary         male system testis         male system prostate       Respiratory lung         Skin/Tegument skin       moderately Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Connective adipose     predominantly Lymphoid         Muscular smooth

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage
cell lines
fluid/secretion	highly in lymph

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a CH (calponin-homology) domain
	a calponin-like repeat

conjugated

Other

HOMOLOGY

interspecies	homolog to zebrafish SM22alpha
	homolog to rattus Tagln2 (97 pc)
	homolog to murine Tagln2 (96.5 pc)

intraspecies

homolog to transgelin a early marker of smooth muscle differentiation

Homologene

FAMILY

calponin family

CATEGORY

unknown/unspecified , transcription factor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytoskeleton
	intracellular,nuclear envelope

basic FUNCTION

actin-binding protein shown to be a tumor suppressor

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

text	muscle development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	maybe actin binding
	unphosphorylated TAGLN2 in CDK14-suppressed cells elicited strong actin-binding ability, a mechanism that possibly halts the actin cytoskeleton dynamics

cell & other

REGULATION

Other

acetylated

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   PTTG1 and TAGLN2 are highly expressed in human pancreatic cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

cross-section of zebrafish SM22alpha-deficient embryo suggests that SM22alpha may play roles in smooth muscle cell morphology transform