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FLASH GENE
Symbol TAF9B contributors: mct - updated : 16-06-2020
HGNC name TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
HGNC id 17306
Location Xq21.1      Physical location : 77.385.245 - 77.395.179
Synonym name
  • neuronal cell death-related protein
  • transcription associated factor 9B
  • transcription associated factor TAFII31L
  • transcription initiation factor IID, 31kD subunit
  • Synonym symbol(s) DN7, DN-7, TAFII31L, TFIID-31, RP4-570L12.2, TAF9L, TAFII31
    EC.number 2.7.4.3
    DNA
    TYPE functioning gene
    STRUCTURE 9.90 kb     7 Exon(s)
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2657 - 251 - 2005 15899866
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     salivary gland    
    Endocrineneuroendocrinepituitary   
    Urinarybladder    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies paralog to TAF9
    Homologene
    FAMILY TAF9 family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in transcriptional activation as well as repression of distinct but overlapping sets of genes
  • may have a role in gene regulation associated with apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TAF9B is a coactivator for the TP53 protein
  • TAF9B binds to both promoters and distal enhancers of neuronal genes, partially co-localizing at binding sites of OLIG2, a key activator of motor neuron differentiation
  • through its acidic transactivation domain (TAD), RELA has the capacity to form interactions with several different transcriptional regulatory proteins, including GTF2B, GTF2H1, EP300 and TAF9B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS