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FLASH GENE
Symbol TAF9 contributors: mct - updated : 09-7-2009
HGNC name TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
HGNC id 11542
Location 5q11.2-q13.1      Physical location : 68.647.554 - 68.665.840
Synonym name
  • TBP associated factor 9
  • coilin-interacting nuclear ATPase protein (TAF9 splice variant)
  • transcription initiation factor TFIID 31 kD subunit
    • Synonym symbol(s) TAFII32, TAF2G, CINAP, CIP, MGC1603, MGC3647, MGC5067, MGC:1603, MGC:3647, MGC:5067, TAFII31, TAFIID32
    EC.number 2.7.4.3
    DNA
    TYPE functioning gene
    STRUCTURE 18.29 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC206227 5q13.1 similar to B-cell lymphoma 9 protein (Bcl-9) (Legless homolog) LOC359819 5q12.3 mitochondrial ribosomal protein L39 pseudogene EEF1B3 5q12-q14 eukaryotic translation elongation factor 1 beta 3 PIK3R1 5q12-q13 phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) SLC30A5 5q12.1 solute carrier family 30 (zinc transporter), member 5 CCNB1 5q11-q12 cyclin B1 CENPH 5p15.2 centromere protein H MRPS36 5q13.3 mitochondrial ribosomal protein S36 CDK7 2p15-pcen cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) KENAE 5q13.1 Kenae LOC285653 5q13.1 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein TAF9 5q12 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa RAD17 5q12-q13.1 RAD17 homolog (S. pombe) FLJ30532 5q13.1 hypothetical protein FLJ30532 OCLN 5q13.1 occludin GTF2H2 5q13.1 general transcription factor IIH, polypeptide 2, 44kDa BIRC1 5q13.1 baculoviral IAP repeat-containing 1 SMN1 5q13.1 survival of motor neuron 1, telomeric LOC391791 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 SMA3 5q13 SMA3 LOC389294 5 similar to bA110H4.2 (similar to membrane protein) LOC391792 5 similar to SMA3 protein LOC340089 5q13.2 similar to bA110H4.2 (similar to membrane protein) LOC391793 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 SERF1A 5q13.1 small EDRK-rich factor 1A (telomeric) SMN2 5q13.1 survival of motor neuron 2, centromeric LOC389295 5 LOC389295 LOC389296 5 similar to Beta-glucuronidase precursor (Beta-G1) LOC389297 5 similar to bA110H4.2 (similar to membrane protein) LOC389298 5 similar to bA110H4.2 (similar to membrane protein) LOC389299 5 similar to Beta-glucuronidase precursor (Beta-G1)
    RNA
    TRANSCRIPTS type messenger
    text TSPYL2 and TAF9 mRNAs are translated from different ATG codons and use distinct reading frames, resulting in them having no identity in their respective protein sequences
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 splicing 1245 - 264 - Lu, Lim, Sengupta (2009)
    5 splicing 962 - 172 - Lu, Sengupta
    5 - 1199 - 169 - Lim, Sengupta (2009)
    3 - 1482 - 264 - Lim, Sengupta (2009)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Reproductivefemale systemuterus  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		a P-loop nucleotide binding motif and ATPase activity
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text specifically nuclear and distributed in a widespread, diffuse nucleoplasmic pattern, excluding nucleoli, with some concentration also in Cajal bodies
    basic FUNCTION
  • functionally supports KLF1 activity by enhancing its ability to activate the beta-globin gene (Sengupta 2009)
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the mammalian STAGA (SUPT3H-TAF9-TADA1-KAT2A-SUPT7L acetyltransferase) a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors (Martinez 2001)
  • TBR1–CASK–TAF9 complex regulates expression of the NMDA receptor subunit 2b (GRIN2B) (Huang 2009)
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TATA box binding (TBP)
  • interacting with the herpes simplex acidic virus transactivator protein 16 (VP16) as well as with the general transcription factor TFIIB
  • interacting with COIL (carboxyl-terminal residues of coilin appear essential for the interaction)
  • interacts with a conserved beta-globin downstream promoter element, and ablation of this interaction by beta-thalassemia-causing mutations decreases its promoter activity and disables superactivation (Sengupta 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS