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FLASH GENE
Symbol TAF8 contributors: npt/ - updated : 07-09-2004
HGNC name TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
HGNC id 17300
Location 6p21.1      Physical location : 42.018.250 - 42.048.643
Synonym name
  • TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50 kD
  • taube nuss homolog (mouse)
  • TBP-associated factor 8
    • Synonym symbol(s) FLJ32821, TBN, TAF(II)43, TAF
    DNA
    TYPE functioning gene
    STRUCTURE 30.39 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 4323 - 310 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a bromodomain
    • HOMOLOGY
    interspecies homolog to murine Tbn
    homolog to rattus LOC316216
    Homologene
    FAMILY
  • TAF8 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • TATA box binding protein associated factor
  • RNA polymerase activity
  • acts as a positive regulator of adipogenesis and reverses the inhibitory effect of its histone fold
  • with SUP7TL-TAF10 and also the SMAT complex, seem to be important regulators of the composition of different TBP and/or STAGA/TFTC complexes in the nucleus and consequently may play a role in gene regulation (Demeny 2007)
    • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • three histone fold-containing interaction partners: TAF3, TAF10, and SUPT7L (Soutoglou 2005)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS