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FLASH GENE
Symbol TAF4B contributors: mct - updated : 21-05-2014
HGNC name TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
HGNC id 11538
Location 18q11.2      Physical location : 23.806.408 - 23.971.647
Synonym name
  • TBP associated factor C2
  • TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD
  • transcription initiation factor TFIID subunit 4B
  • Synonym symbol(s) TAF2C2, TAFII105, TAFII105ALPHA
    DNA
    TYPE functioning gene
    STRUCTURE 165.38 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure
  • non-canonical E-box in the TAF4B promoter
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC390840 18 similar to ribosomal protein S4, X-linked LOC390841 18 similar to ubiquitin-conjugating enzyme E2C isoform 2; ubiquitin carrier protein E2-C; ubiquitin-protein ligase C; cyclin-selective ubiquitin carrier protein; mitotic-specific ubiquitin-conjugating enzyme RBBP8 18q11.2 retinoblastoma binding protein 8 LOC91768 MGC11386 18q11.2 hypothetical protein MGC11386 RIOK3 18q11.2 RIO kinase 3 (yeast) C18orf8 18q11.2 chromosome 18 open reading frame 8 NPC1 18q11.1-q11.2 Niemann-Pick disease, type C1 LOC147463 18q11.2 hypothetical protein LOC147463 LOC390842 18 similar to 40S ribosomal protein S10 LAMA3 18q11.2 laminin, alpha 3 FLJ33761 18q11.2 hypothetical protein FLJ33761 CABYR 18q11.1 calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2) OSBPL1A 18q11-q12 oxysterol binding protein-like 1A IMPACT 18q11.2-q12.1 hypothetical protein IMPACT HRH4 18q11.2 histamine receptor H4 LOC390843 18 similar to hypothetical protein BC005868 LOC342741 18q11.2 similar to DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 LOC147468 18q11.2 similar to WW domain binding protein 2 EHZF 18q11.2 early hematopoietic zinc finger SS18 18q11.2 synovial sarcoma translocation, chromosome 18 MGC26605 18q11.2 hypothetical protein MGC26605 TAF4B 18q11.2 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa KCTD1 18 potassium channel tetramerisation domain containing 1 LOC388472 18 hypothetical gene supported by BC002568 LOC342695 18q12.1 similar to ubiquitin fusion degradation 1-like AQP4 18q11.2.q12.1 aquaporin 4 FLJ30507 18q12.1 hypothetical protein FLJ30507 CHST9 18q11.2 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 LOC342697 18q12.1 similar to Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) CDH2 18q11.2-q12.2 cadherin 2, type 1, N-cadherin (neuronal) LOC390844 18 similar to Ariadne-2 protein homolog (ARI-2) (Triad1 protein) (HT005)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 4777 91 862 - 2005 15601843
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale system   highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticprogenitor cell Homo sapiens
    Reproductivespermatid Homo sapiens
    Reproductivespermatocyte Homo sapiens
    Reproductivespermatogonia Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal domain
  • two p65/RelA binding domains
  • a highly C terminal domain related shared by TAFII 130 and TAFII 110
  • HOMOLOGY
    intraspecies homolog to related to TAFII 130
    Homologene
    FAMILY
  • TAF4 family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • transactivator of B-cell (and ovary) specific genes
  • synergistic role for TAF4B and JUN and other AP1 family members on the promoter of ITGA6, underlining the existence of a specific mechanism related to gene expression control
  • is required for the initial establishment of the primordial follicle reserve at birth
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text ovarian development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to a subset of NF-kappa B gene
    RNA
    small molecule
    protein
  • OBF1 (POU2AF1)
  • MOV10L1 expression is sensitive to TAF4B level, linking TAF4B to the posttranscriptional control of ovarian gene expression
  • DNA binding by TAF4/TAF4B-TAF12 facilitates the association of TBP with the core promoter of a subset of genes
  • cooperates with POU5F1 to regulate a subset of genes in ESC, whereas TAF4 is required for later embryonic developmental stages
  • cell & other
    REGULATION
    induced by MYC, that directly induces TAF4B expression, through one of the non-canonical E-box sites, which is in a highly conserved region of TAF4B promoters
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    homozygous truncating mutations p.R611X in TAF4B in azoospermia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • TAFII 105defective mice, display a defect in ovarian development (folliculogenesis)
  • rapid decline of ovarian function in Taf4b-null mice begins in early postnatal life, and follicle depletion is completed by 16 wk of age