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FLASH GENE

Symbol

TAF13

contributors: mct - updated : 14-04-2017

HGNC name	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
HGNC id	11546

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MCPH18 microcephaly 18, primary
Location	1p13.3      Physical location : 109.606.997 - 109.618.624
Synonym name	TBP-associated factor 13
	transcription initiation factor TFIID 18 kD subunit
Synonym symbol(s)	TAF2K, TAFII18, T2DB, MGC22425, TAF(II)18, TAFII-18

DNA

TYPE	functioning gene
STRUCTURE	11.63 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005645 4 - 577 NP_005636 14.3 124 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive liver       moderately Endocrine pancreas       moderately Reproductive male system prostate     moderately Respiratory lung         Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to C.elegans tkr-1

Homologene

FAMILY

TAF13 family

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,nucleolus

basic FUNCTION	involved in the initiation of transcription by RNA polymerase 2
	importance of TAF13 in neuronal functions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

TAF13 and TAF11 form a histone-like heterodimer that is essential for their recruitment into the general RNA polymerase II transcription factor IID (TFIID) complex

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MCPH18

Susceptibility

to schizophrenia

Variant & Polymorphism other	rare cases of schizophrenia caused by de novo mutations of TAF13

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS