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FLASH GENE
Symbol TAF12 contributors: mct - updated : 24-05-2014
HGNC name TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
HGNC id 11545
Location 1p35.3      Physical location : 28.929.610 - 28.969.604
Synonym name
  • TATA box binding protein (TBP)-associated factor, RNA polymerase II, J, 20kD
  • transcription initiation factor TFIID 20/15 kDa subunits
  • transcription initiation factor TFIID subunit 12
  • Synonym symbol(s) TAF2J, TAFII20, T2DA, TAFII20/TAFII15
    DNA
    TYPE functioning gene
    STRUCTURE 40.01 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1129 17 161 - -
    6 - 1466 - 161 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • TAF12 family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the initiation of transcription by RNA polymerase 2
  • importance of TAF12 in the process of RAS-induced transformation properties of human colon cells and epithelial to mesenchymal transition
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • mediates ATF7 transcriptional activity through direct interactions between the two proteins
  • recruits GADD45A and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation
  • DNA binding by TAF4/TAF4B-TAF12 facilitates the association of TBP with the core promoter of a subset of genes
  • ATF7 interacts with TAF12 and contributes to the hypersensitivity of Osteoclast (OCL) precursors to 1,25-(OH)&
  • 8322;D&
    8323; in in Paget disease
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS