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Symbol TAF11 contributors: mct - updated : 14-04-2017
HGNC name TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
HGNC id 11544
Location 6p21.31      Physical location : 34.845.554 - 34.855.819
Synonym name
  • TBP associated factor 11
  • TFIID subunit p30-beta
  • transcription initiation factor TFIID subunit 11
  • Synonym symbol(s) TAF2I, TAFII28, T2D9, PRO2134, MGC:15243, TAF, p30-beta
    DNA
    TYPE functioning gene
    STRUCTURE 10.29 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1587 23 211 - 2003 14574404
    4 - 1490 - 154 - 2003 14574404
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Nervousbrain   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines chondrosarcoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • TAF2I family
  • TAF11 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the initiation of transcription by RNA polymerase 2
  • maybe involved in lung carcinoma
  • may have dual functions: a nuclear transcription function that is required for viability and development, and a cytoplasmic function in RNAi
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • TAF11 heterodimerizes with TAF13 in the nucleus
  • TAF13 and TAF11 form a histone-like heterodimer that is essential for their recruitment into the general RNA polymerase II transcription factor IID (TFIID) complex
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TATA box binding (TBP)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS