basic FUNCTION
| transcriptional activator adaptor, part of the PCAF histone acetylase complex, associated with the tumor suppressor protein TP53 and required for full activity of TP53 and TP53-mediated apoptosis |
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component of coactivator complexes that include histone acetyltransferase p300/CREB-binding protein, as a critical mediator of acetylation-dependent stabilization and activation of TP53 upon genotoxic stress in mammalian cells |
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functioning as a coactivator for TP53-mediated transactivation by stabilizing TP53 protein |
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functioning as a coactivator for retinoid receptor-mediated transcriptional activation |
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important role in histone acetyl transferases recruitment to estrogen-responsive target gene promoters and for estrogen-dependent proliferation of breast cancer cells |
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endogenous TADA3 is essential for DNA damage-induced acetylation and stabilization of TP53 as well as TP53 target gene induction |
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regulates CDKN2A-induced TP53 acetylation and senescence |
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with TADA2A, are crucial cofactors of beta-catenin likely involved in the assembly of transactivation-competent beta-catenin complexes at Wnt target genes |
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transcriptional coactivator for RARA, acting through a conserved mechanism involving direct contacts between nuclear receptor boxes and the receptor co-activator pocket |
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may direct the action of multi-functional co-activator complexes toward modulating nuclear receptor signaling |
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is an essential component of histone acetyl transferase containing coactivator complexes |
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critical role of TADA3 in embryogenesis and cell cycle progression as an essential component of HAT complex |
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existence of a novel cell cycle-associated, TADA3-regulated signaling pathway that promotes G1/S cell cycle progression by regulating CDKN1B stability through MYC-dependent control of SKP2 expression |
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a novel role for TADA3 in maintenance of the DNA repair process and genomic stability |
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important role of TADA3 in mitosis |