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FLASH GENE
Symbol TADA3 contributors: mct/ - updated : 23-09-2015
HGNC name transcriptional adaptor 3
HGNC id 19422
Location 3p25.3      Physical location : 9.821.653 - 9.834.420
Synonym name
  • transcriptional adaptor 3 (NGG1 homolog, yeast)-like
  • transcriptional adaptor 3-like
  • ADA3 homolog
  • alteration/deficiency in activation 3
  • Synonym symbol(s) FLJ20221, FLJ21329, ADA3, STAF54, TADA3L, NGG1, STAF54L, hADA3
    DNA
    TYPE functioning gene
    STRUCTURE 13.05 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2245 - 432 - 2008 18059173
    8 - 2571 - 369 - 2008 18059173
    9 - 1924 - 432 - 2008 18059173
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunethymus   highly Mus musculusAdult
    Reproductivefemale systembreastmammary gland highly Mus musculusAdult
     female systemovary  highly
    Respiratorylung   highly Mus musculusAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • classical LxxLL motifs, CoRNR boxes, adopting a short alpha-helical structure and docking into a hydrophobic co-activator-binding pocket surrounded by helices H3, H4, H5 and H12 of the LBD
  • HOMOLOGY
    interspecies homolog to murine Ada3
    homolog to yeast transcriptional coactivator yADA3
    Homologene
    FAMILY
  • NGG1 family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional activator adaptor, part of the PCAF histone acetylase complex, associated with the tumor suppressor protein TP53 and required for full activity of TP53 and TP53-mediated apoptosis
  • component of coactivator complexes that include histone acetyltransferase p300/CREB-binding protein, as a critical mediator of acetylation-dependent stabilization and activation of TP53 upon genotoxic stress in mammalian cells
  • functioning as a coactivator for TP53-mediated transactivation by stabilizing TP53 protein
  • functioning as a coactivator for retinoid receptor-mediated transcriptional activation
  • important role in histone acetyl transferases recruitment to estrogen-responsive target gene promoters and for estrogen-dependent proliferation of breast cancer cells
  • endogenous TADA3 is essential for DNA damage-induced acetylation and stabilization of TP53 as well as TP53 target gene induction
  • regulates CDKN2A-induced TP53 acetylation and senescence
  • with TADA2A, are crucial cofactors of beta-catenin likely involved in the assembly of transactivation-competent beta-catenin complexes at Wnt target genes
  • transcriptional coactivator for RARA, acting through a conserved mechanism involving direct contacts between nuclear receptor boxes and the receptor co-activator pocket
  • may direct the action of multi-functional co-activator complexes toward modulating nuclear receptor signaling
  • is an essential component of histone acetyl transferase containing coactivator complexes
  • critical role of TADA3 in embryogenesis and cell cycle progression as an essential component of HAT complex
  • existence of a novel cell cycle-associated, TADA3-regulated signaling pathway that promotes G1/S cell cycle progression by regulating CDKN1B stability through MYC-dependent control of SKP2 expression
  • a novel role for TADA3 in maintenance of the DNA repair process and genomic stability
  • important role of TADA3 in mitosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • essential component of the PCAF complex
  • essential component of the ADA transcriptional coactivator complex composed of ADA2, ADA3, and a HAT component GCN5
  • core component of HAT containing coactivator complexes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ESR1 and ESR2(enhances the transcription of ER-responsive genes, suggesting a broader role as a coactivator of nuclear hormone receptors and the potential role of these pathways in HPV oncogenesis)
  • newly identified target of the ANKRD proteins, which may modulate co-activator function in a transcription-factor-specific manner
  • interacts directly with RARA in a hormone-dependent manner and this interaction contributes to RARA transactivation
  • binds and stabilizes the tumor suppressor TP53 protein and is required for TP53 acetylation by EP300
  • important role of TADA3-dependent control of CDKN1B levels in promoting cell cycle progression
  • TADA3-interacting partners, are AATF (apoptosis-antagonizing transcription factor), and regulatory subunits of the PP1 and PP2A [PPP1R7 and PPP2R5D]
  • KAT2B and TADA3 regulate BID processing via PACS2, to modulate the mitochondrial cell death pathway in response to GZMB
  • TADA3 is required for the loading of CENPB onto the centromeres
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Ada3-null mice embryos undergo very early lethality