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FLASH GENE
Symbol TADA2A contributors: mct/npt - updated : 09-12-2009
HGNC name transcriptional adaptor 2A
HGNC id 11531
Location 17q12      Physical location : 35.766.976 - 35.837.224
Synonym name
  • transcriptional adaptor 2 (ADA2 homolog, yeast)-like
  • ADA2-like protein
  • transcriptional adaptor 2 (ADA2, yeast, homolog)-like
  • Synonym symbol(s) ADA2, KL04P, FLJ12705, TADA2L, ADA2A
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    text head to head with ACACA
    STRUCTURE 69.91 kb     11 Exon(s)
    regulatory sequence Promoter
    text structure bidirectional promoter coregulating transcripts derived from TADA2L and ACACA
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 1886 - 443 - 2008 18059173
    11 - 1327 - 305 - 2008 18059173
    - - 1678 - 443 - 2008 18059173
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SWIRM domain, having a functional role in chromatin remodeling
  • HOMOLOGY
    interspecies homolog to yeast ADA2 transcriptional adaptor
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • enhancing the initial rate of RNA polymearse II mediated transcription
  • with TADA3, are crucial cofactors of beta-catenin likely involved in the assembly of transactivation-competent beta-catenin complexes at Wnt target genes
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GCN5L2
  • physically interact with CTNNB, and the interaction is mediated through Armadillo repeats 6 through 12 and the C-terminal transactivation domain of beta-catenin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS