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FLASH GENE

Symbol

TACR2

contributors: mct - updated : 03-11-2009

HGNC name	tachykinin receptor 2
HGNC id	11527

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q22.1      Physical location : 71.163.957 - 71.176.674
Synonym name	NK-2 receptor
	neurokinin 2 receptor
	seven transmembrane helix receptor
	substance K receptor
Synonym symbol(s)	NK-2R, NKNAR, TAC2R, SKR, NK2R

DNA

TYPE	functioning gene
STRUCTURE	12.72 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 826 isoform 1 - - bladder, uterus, colon, duodenum 2002 12427486 also called TACR2 alpha variant 2 - splicing 631 isoform 2 - - uterus 2002 12427486 also called TACR2 beta NM_001057 5 - 2416 NP_001048 - 398 - 1991 1661704

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   predominantly Homo sapiens Nervous brain         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular smooth ciliary muscle     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

signaling hormone , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	having a tachykinin receptor activity and rhodopsin-like receptor activity
	regulate hematopoiesis by interacting with neurotransmitters that belong to the tachykinin
	involvement in the regulation of intestinal motility
	major involvement in the regulation of human colonic functions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with tachykinin 2 receptor, neurokinin A receptor (substance K)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS