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FLASH GENE
Symbol TACR2 contributors: mct - updated : 03-11-2009
HGNC name tachykinin receptor 2
HGNC id 11527
Location 10q22.1      Physical location : 71.163.957 - 71.176.674
Synonym name
  • NK-2 receptor
  • neurokinin 2 receptor
  • seven transmembrane helix receptor
  • substance K receptor
  • Synonym symbol(s) NK-2R, NKNAR, TAC2R, SKR, NK2R
    DNA
    TYPE functioning gene
    STRUCTURE 12.72 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LCX 10q21 leukemia-associated protein with a CXXC domain CARP-1 10q22.1 cell-cycle and apoptosis regulatory protein 1 C10orf24 10q22.1 chromosome 10 open reading frame 24 DDX50 10q22.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 DDX21 10q21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 KIAA1279 10q22.1 KIAA1279 LOC389976 10 similar to actin 3 - fruit fly (Drosophila melanogaster) (fragments) PRG1 10q22.1 proteoglycan 1, secretory granule VPS26 10q21.1 vacuolar protein sorting 26 (yeast) SUPV3L1 10q22.1 suppressor of var1, 3-like 1 (S. cerevisiae) FLJ22761 10q22.1 hypothetical protein FLJ22761 HK1 10q22 hexokinase 1 TACR2 10q22.1 tachykinin receptor 2 NET-7 10q22.1 transmembrane 4 superfamily member tetraspan NET-7 NEUROG3 10q21.3 neurogenin 3 C10orf35 10q22.2 chromosome 10 open reading frame 35 LOC389977 10 similar to ribosomal protein L5; 60S ribosomal protein L5 COL13A1 10q21.2-q22.1 collagen, type XIII, alpha 1 LOC387686 10 LOC387686 H2AFY2 10q22.3 H2A histone family, member Y2 AMID 10q22.2 apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death MGC34695 10q22.2 hypothetical protein MGC34695 SARA1 10q22.2 SAR1a gene homolog 1 (S. cerevisiae) CALM2P2 10q22.2 calmodulin 2 pseudogene 2 PP 10q22.1-q22.2 pyrophosphatase (inorganic)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 826 - - bladder, uterus, colon, duodenum 2002 12427486
    also called TACR2 alpha
    - splicing 631 - - uterus 2002 12427486
    also called TACR2 beta
    5 - 2416 - 398 - 1991 1661704
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon predominantly Homo sapiens
    Nervousbrain     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothciliary muscle   Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having a tachykinin receptor activity and rhodopsin-like receptor activity
  • regulate hematopoiesis by interacting with neurotransmitters that belong to the tachykinin
  • involvement in the regulation of intestinal motility
  • major involvement in the regulation of human colonic functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with tachykinin 2 receptor, neurokinin A receptor (substance K)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS