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FLASH GENE
Symbol TACR1 contributors: mct - updated : 22-10-2013
HGNC name tachykinin receptor 1
HGNC id 11526
Location 2p13.1      Physical location : 75.273.589 - 75.426.645
Synonym name
  • neurokinin 1 receptor
  • tachykinin receptor 1 (substance P receptor)
  • Synonym symbol(s) NK1R, TAC1R, SPR
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 153.06 kb     5 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    NSPC1 2p13.1 likely ortholog of mouse nervous system polycomb 1 TLX2 2p13.1-p12 T-cell leukemia, homeobox 2 DQX1 2p12 T-cell leukemia, homeobox 2 AUP1 2p13 ancient ubiquitous protein 1 PRSS25 2p13.3 protease, serine, 25 LOXL3 2p13.3 lysyl oxidase-like 3 DOK1 2p13 docking protein 1, 62kDa (downstream of tyrosine kinase 1) LOC130951 2p13.1 hypothetical protein BC014602 SEMA4F 2p13 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F HK2 2p13.1 hexokinase 2 POLE4 2p12 polymerase (DNA-directed), epsilon 4 (p12 subunit) TACR1 2p13-p11 tachykinin receptor 1 LOC388964 2 LOC388964 FLJ13391 2p12 hypothetical protein FLJ13391
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 4795 - 407 . highly expressed in breast cells . significantly decreased in breast tumor, particularly in metastatic carcinomas 2013 23807418
  • TACR1L
  • functional
  • 4 splicing 1732 - 311 highly expressed in breast cancer cells 2013 23807418
  • TACR1S, NK1R-Tr
  • functional
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node     Homo sapiens
     spleen   highly Homo sapiens
    Reproductivefemale systembreast  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunenatural killer Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • an extracellular loop (E2) involved in the binding of substance P (TAC1)
  • HOMOLOGY
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY signaling hormone , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text localized in lipid rafts, and activation of TACR1 stimulates translocation of PKC into lipid rafts, where it interacts with the receptor and causes its desensitization
    basic FUNCTION
  • involved in mucosal immunomodulation in the mediation of phosphotidyl inositol metabolism of TAC1
  • plays an important role in nociception, and involved in thermal hyperalgesia mediated by directly sensitizing C-type sensory afferents
  • TAC1/TACR1 system, leads to the activation of nuclear factor-kappa B (NFKB) and proinflammatory cytokines
  • role for TAC1/TACR1 interactions in adipose tissue responses, specifically as they relate to obesity-associated pathologies such as glucose intolerance and insulin resistance
  • involvement of TACR1 signalling in adult hematopoiesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component TACR1 forms physical complexes with SLC6A2
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • tachykinin 1 receptor, substance P/neurokinine 1 receptor
  • TAC1/TACR1 system is a major class 1, rhodopsin-like GPCR ligand-receptor interaction
  • TAC1/TACR1 interaction upregulates monocyte tissue factor
  • was a potential regulator of human glioma cell migration by the up-regulation of MMP2 and MMP14
  • mediates down-regulation of SLC6A2 via protein kinase C (PKC)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the pancreatic cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    treatment of TACR1 antagonist exerted antitumor action in breast cancer cells with NK1R-Tr high expression
    cancerdigestivepancreas
    blocking the TAC1/TACR1 signaling system is a novel strategy for the treatment of pancreatic cancer
    miscelleaneousvascular 
    antagonists (NK1-RA) may have a role in developing novel therapeutic approaches to patients vulnerable to vaso-occlusive disorders
    ANIMAL & CELL MODELS
  • bone marrow taken from Nk1r deficient mice (Tacr1(-/-) showed lineage specific B and T cell engraftment deficits compared to wild-type competitor bone marrow cells